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Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation

BACKGROUND: Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy the spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing aneuploidy. The mitotic checkpoint complex (MCC), comprising MAD1, MAD2, Cdc20, B...

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Detalles Bibliográficos
Autores principales:	Zhao, Juan, Li, Hui, Chen, Guangxin, Du, Lijun, Xu, Peiyan, Zhang, Xiaoli, Xie, Min, Cao, Tiansheng, Li, Haibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074413/ https://www.ncbi.nlm.nih.gov/pubmed/33902659 http://dx.doi.org/10.1186/s13039-021-00538-1

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