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Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol

INTRODUCTION: Targeted, tailored interventions to test high-risk individuals for HIV and hepatitis C virus (HCV) are vital to achieving HIV control and HCV microelimination in Africa. Compared with the general population, people who inject drugs (PWID) are at increased risk of HIV and HCV and are le...

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Autores principales: Monroe-Wise, Aliza, Mbogo, Loice, Guthrie, Brandon, Bukusi, David, Sambai, Betsy, Chohan, Bhavna, Scott, John, Cherutich, Peter, Musyoki, Helgar, Bosire, Rose, Dunbar, Matthew, Macharia, Paul, Masyuko, Sarah, Wilkinson, Eduan, De Oliveira, Tulio, Ludwig-Barron, Natasha, Sinkele, Bill, Herbeck, Joshua, Farquhar, Carey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074565/
https://www.ncbi.nlm.nih.gov/pubmed/33895711
http://dx.doi.org/10.1136/bmjopen-2020-041083
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author Monroe-Wise, Aliza
Mbogo, Loice
Guthrie, Brandon
Bukusi, David
Sambai, Betsy
Chohan, Bhavna
Scott, John
Cherutich, Peter
Musyoki, Helgar
Bosire, Rose
Dunbar, Matthew
Macharia, Paul
Masyuko, Sarah
Wilkinson, Eduan
De Oliveira, Tulio
Ludwig-Barron, Natasha
Sinkele, Bill
Herbeck, Joshua
Farquhar, Carey
author_facet Monroe-Wise, Aliza
Mbogo, Loice
Guthrie, Brandon
Bukusi, David
Sambai, Betsy
Chohan, Bhavna
Scott, John
Cherutich, Peter
Musyoki, Helgar
Bosire, Rose
Dunbar, Matthew
Macharia, Paul
Masyuko, Sarah
Wilkinson, Eduan
De Oliveira, Tulio
Ludwig-Barron, Natasha
Sinkele, Bill
Herbeck, Joshua
Farquhar, Carey
author_sort Monroe-Wise, Aliza
collection PubMed
description INTRODUCTION: Targeted, tailored interventions to test high-risk individuals for HIV and hepatitis C virus (HCV) are vital to achieving HIV control and HCV microelimination in Africa. Compared with the general population, people who inject drugs (PWID) are at increased risk of HIV and HCV and are less likely to be tested or successfully treated. Assisted partner services (APS) increases HIV testing among partners of people living with HIV and improves case finding and linkage to care. We describe a study in Kenya examining whether APS can be adapted to find, test and link to HIV care the partners of HIV-positive PWID using a network of community-embedded peer educators (PEs). Our study also identifies HCV-positive partners and uses phylogenetic analysis to determine risk factors for onward transmission of both viruses. METHODS: This prospective cohort study leverages a network of PEs to identify 1000 HIV-positive PWID for enrolment as index participants. Each index completes a questionnaire and provides names and contact information of all sexual and injecting partners during the previous 3 years. PEs then use a stepwise locator protocol to engage partners in the community and bring them to study sites for enrolment, questionnaire completion and rapid HIV and HCV testing. Outcomes include number and type of partners per index who are mentioned, enrolled, tested, diagnosed with HIV and HCV and linked to care. ETHICS AND DISSEMINATION: Potential index participants are screened for intimate partner violence (IPV) and those at high risk are not eligible to enrol. Those at medium risk are monitored for IPV following enrolment. A community advisory board engages in feedback and discussion between the community and the research team. A safety monitoring board discusses study progress and reviews data, including IPV monitoring data. Dissemination plans include presentations at quarterly Ministry of Health meetings, local and international conferences and publications. TRIAL REGISTRATION NUMBER: NCT03447210, Pre-results stage.
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spelling pubmed-80745652021-05-11 Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol Monroe-Wise, Aliza Mbogo, Loice Guthrie, Brandon Bukusi, David Sambai, Betsy Chohan, Bhavna Scott, John Cherutich, Peter Musyoki, Helgar Bosire, Rose Dunbar, Matthew Macharia, Paul Masyuko, Sarah Wilkinson, Eduan De Oliveira, Tulio Ludwig-Barron, Natasha Sinkele, Bill Herbeck, Joshua Farquhar, Carey BMJ Open HIV/AIDS INTRODUCTION: Targeted, tailored interventions to test high-risk individuals for HIV and hepatitis C virus (HCV) are vital to achieving HIV control and HCV microelimination in Africa. Compared with the general population, people who inject drugs (PWID) are at increased risk of HIV and HCV and are less likely to be tested or successfully treated. Assisted partner services (APS) increases HIV testing among partners of people living with HIV and improves case finding and linkage to care. We describe a study in Kenya examining whether APS can be adapted to find, test and link to HIV care the partners of HIV-positive PWID using a network of community-embedded peer educators (PEs). Our study also identifies HCV-positive partners and uses phylogenetic analysis to determine risk factors for onward transmission of both viruses. METHODS: This prospective cohort study leverages a network of PEs to identify 1000 HIV-positive PWID for enrolment as index participants. Each index completes a questionnaire and provides names and contact information of all sexual and injecting partners during the previous 3 years. PEs then use a stepwise locator protocol to engage partners in the community and bring them to study sites for enrolment, questionnaire completion and rapid HIV and HCV testing. Outcomes include number and type of partners per index who are mentioned, enrolled, tested, diagnosed with HIV and HCV and linked to care. ETHICS AND DISSEMINATION: Potential index participants are screened for intimate partner violence (IPV) and those at high risk are not eligible to enrol. Those at medium risk are monitored for IPV following enrolment. A community advisory board engages in feedback and discussion between the community and the research team. A safety monitoring board discusses study progress and reviews data, including IPV monitoring data. Dissemination plans include presentations at quarterly Ministry of Health meetings, local and international conferences and publications. TRIAL REGISTRATION NUMBER: NCT03447210, Pre-results stage. BMJ Publishing Group 2021-04-24 /pmc/articles/PMC8074565/ /pubmed/33895711 http://dx.doi.org/10.1136/bmjopen-2020-041083 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle HIV/AIDS
Monroe-Wise, Aliza
Mbogo, Loice
Guthrie, Brandon
Bukusi, David
Sambai, Betsy
Chohan, Bhavna
Scott, John
Cherutich, Peter
Musyoki, Helgar
Bosire, Rose
Dunbar, Matthew
Macharia, Paul
Masyuko, Sarah
Wilkinson, Eduan
De Oliveira, Tulio
Ludwig-Barron, Natasha
Sinkele, Bill
Herbeck, Joshua
Farquhar, Carey
Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title_full Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title_fullStr Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title_full_unstemmed Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title_short Peer-mediated HIV assisted partner services to identify and link to care HIV-positive and HCV-positive people who inject drugs: a cohort study protocol
title_sort peer-mediated hiv assisted partner services to identify and link to care hiv-positive and hcv-positive people who inject drugs: a cohort study protocol
topic HIV/AIDS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074565/
https://www.ncbi.nlm.nih.gov/pubmed/33895711
http://dx.doi.org/10.1136/bmjopen-2020-041083
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