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Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis

(1) Background: Our aim was to analyze the incidence, procedures, and in-hospital outcomes of myocardial infarction (MI) in Spain (2016–2018) according to sex. (2) Methods: We estimated the incidence of an ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI)...

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Autores principales: de Miguel-Yanes, José M., Jiménez-García, Rodrigo, Hernandez-Barrera, Valentin, de Miguel-Díez, Javier, Muñoz-Rivas, Nuria, Méndez-Bailón, Manuel, Pérez-Farinós, Napoleón, López-Herranz, Marta, Lopez-de-Andres, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074598/
https://www.ncbi.nlm.nih.gov/pubmed/33924190
http://dx.doi.org/10.3390/jcm10081795
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author de Miguel-Yanes, José M.
Jiménez-García, Rodrigo
Hernandez-Barrera, Valentin
de Miguel-Díez, Javier
Muñoz-Rivas, Nuria
Méndez-Bailón, Manuel
Pérez-Farinós, Napoleón
López-Herranz, Marta
Lopez-de-Andres, Ana
author_facet de Miguel-Yanes, José M.
Jiménez-García, Rodrigo
Hernandez-Barrera, Valentin
de Miguel-Díez, Javier
Muñoz-Rivas, Nuria
Méndez-Bailón, Manuel
Pérez-Farinós, Napoleón
López-Herranz, Marta
Lopez-de-Andres, Ana
author_sort de Miguel-Yanes, José M.
collection PubMed
description (1) Background: Our aim was to analyze the incidence, procedures, and in-hospital outcomes of myocardial infarction (MI) in Spain (2016–2018) according to sex. (2) Methods: We estimated the incidence of an ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to sex using the Spanish National Hospital Discharge Database. A matched-pair analysis was used. (3) Results: MI was coded in 156,826 patients aged ≥18 years (111,842 men and 44,984 women). Men showed higher incidence rates (205.0 vs. 77.8 per 100,000; p < 0.001; IRR = 2.81(95%CI:2.78–2.84)). After matching, the use of coronary artery by-pass grafting (CABG) (1.0% vs. 0.7%; p < 0.001) and percutaneous coronary intervention (PCI) (57.8% vs. 52.3%; p < 0.001) was higher among men with an STEMI, whereas the in-hospital mortality (IHM) remained higher among women (11.2% vs. 10.1%; p < 0.001). Likewise, CABG (1.9% vs. 3.3%; p < 0.001) and PCI (33.8% vs. 41.9%; p < 0.001) were less often used among women with an NSTEMI, but no sex-related differences were found in IHM. After adjusting for confounders, IHM was more than twofold higher for both men and women with an STEMI than those with an NSTEMI. Women with an STEMI had a 21% higher mortality risk than men (OR = 1.21(95%CI:1.13–1.29). (4) Conclusion: Men had higher incidence rates of MI than women. Women underwent invasive procedures less often and had a higher IHM when admitted for an STEMI.
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spelling pubmed-80745982021-04-27 Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis de Miguel-Yanes, José M. Jiménez-García, Rodrigo Hernandez-Barrera, Valentin de Miguel-Díez, Javier Muñoz-Rivas, Nuria Méndez-Bailón, Manuel Pérez-Farinós, Napoleón López-Herranz, Marta Lopez-de-Andres, Ana J Clin Med Article (1) Background: Our aim was to analyze the incidence, procedures, and in-hospital outcomes of myocardial infarction (MI) in Spain (2016–2018) according to sex. (2) Methods: We estimated the incidence of an ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to sex using the Spanish National Hospital Discharge Database. A matched-pair analysis was used. (3) Results: MI was coded in 156,826 patients aged ≥18 years (111,842 men and 44,984 women). Men showed higher incidence rates (205.0 vs. 77.8 per 100,000; p < 0.001; IRR = 2.81(95%CI:2.78–2.84)). After matching, the use of coronary artery by-pass grafting (CABG) (1.0% vs. 0.7%; p < 0.001) and percutaneous coronary intervention (PCI) (57.8% vs. 52.3%; p < 0.001) was higher among men with an STEMI, whereas the in-hospital mortality (IHM) remained higher among women (11.2% vs. 10.1%; p < 0.001). Likewise, CABG (1.9% vs. 3.3%; p < 0.001) and PCI (33.8% vs. 41.9%; p < 0.001) were less often used among women with an NSTEMI, but no sex-related differences were found in IHM. After adjusting for confounders, IHM was more than twofold higher for both men and women with an STEMI than those with an NSTEMI. Women with an STEMI had a 21% higher mortality risk than men (OR = 1.21(95%CI:1.13–1.29). (4) Conclusion: Men had higher incidence rates of MI than women. Women underwent invasive procedures less often and had a higher IHM when admitted for an STEMI. MDPI 2021-04-20 /pmc/articles/PMC8074598/ /pubmed/33924190 http://dx.doi.org/10.3390/jcm10081795 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Miguel-Yanes, José M.
Jiménez-García, Rodrigo
Hernandez-Barrera, Valentin
de Miguel-Díez, Javier
Muñoz-Rivas, Nuria
Méndez-Bailón, Manuel
Pérez-Farinós, Napoleón
López-Herranz, Marta
Lopez-de-Andres, Ana
Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title_full Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title_fullStr Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title_full_unstemmed Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title_short Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in Spain, 2016–2018: A Matched-Pair Analysis
title_sort sex differences in the incidence and outcomes of acute myocardial infarction in spain, 2016–2018: a matched-pair analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074598/
https://www.ncbi.nlm.nih.gov/pubmed/33924190
http://dx.doi.org/10.3390/jcm10081795
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