Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease

Deficits in olfaction and taste are among the most frequent non-motor manifestations in Parkinson’s disease (PD) that start very early and frequently precede the PD motor symptoms. The limited data available suggest that the basis of the olfactory and gustatory dysfunction related to PD are likely m...

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Autores principales: Melis, Melania, Haehner, Antje, Mastinu, Mariano, Hummel, Thomas, Tomassini Barbarossa, Iole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074606/
https://www.ncbi.nlm.nih.gov/pubmed/33924222
http://dx.doi.org/10.3390/ijms22084286
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author Melis, Melania
Haehner, Antje
Mastinu, Mariano
Hummel, Thomas
Tomassini Barbarossa, Iole
author_facet Melis, Melania
Haehner, Antje
Mastinu, Mariano
Hummel, Thomas
Tomassini Barbarossa, Iole
author_sort Melis, Melania
collection PubMed
description Deficits in olfaction and taste are among the most frequent non-motor manifestations in Parkinson’s disease (PD) that start very early and frequently precede the PD motor symptoms. The limited data available suggest that the basis of the olfactory and gustatory dysfunction related to PD are likely multifactorial and may include the same determinants responsible for other non-motor symptoms of PD. This review describes the most relevant molecular and genetic factors involved in the PD-related smell and taste impairments, and their associations with the microbiota, which also may represent risk factors associated with the disease.
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spelling pubmed-80746062021-04-27 Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease Melis, Melania Haehner, Antje Mastinu, Mariano Hummel, Thomas Tomassini Barbarossa, Iole Int J Mol Sci Review Deficits in olfaction and taste are among the most frequent non-motor manifestations in Parkinson’s disease (PD) that start very early and frequently precede the PD motor symptoms. The limited data available suggest that the basis of the olfactory and gustatory dysfunction related to PD are likely multifactorial and may include the same determinants responsible for other non-motor symptoms of PD. This review describes the most relevant molecular and genetic factors involved in the PD-related smell and taste impairments, and their associations with the microbiota, which also may represent risk factors associated with the disease. MDPI 2021-04-20 /pmc/articles/PMC8074606/ /pubmed/33924222 http://dx.doi.org/10.3390/ijms22084286 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Melis, Melania
Haehner, Antje
Mastinu, Mariano
Hummel, Thomas
Tomassini Barbarossa, Iole
Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title_full Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title_fullStr Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title_full_unstemmed Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title_short Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease
title_sort molecular and genetic factors involved in olfactory and gustatory deficits and associations with microbiota in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074606/
https://www.ncbi.nlm.nih.gov/pubmed/33924222
http://dx.doi.org/10.3390/ijms22084286
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