Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer

Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with impro...

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Detalles Bibliográficos
Autores principales: Fu, Boqiao, Li, Yingjie, Peng, Shaoyong, Wang, Xiaolin, Hu, Jingying, Lv, Long, Xia, Caifen, Lu, Dai, Qin, Caiqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074679/
https://www.ncbi.nlm.nih.gov/pubmed/33972860
http://dx.doi.org/10.1098/rsos.201642
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author Fu, Boqiao
Li, Yingjie
Peng, Shaoyong
Wang, Xiaolin
Hu, Jingying
Lv, Long
Xia, Caifen
Lu, Dai
Qin, Caiqin
author_facet Fu, Boqiao
Li, Yingjie
Peng, Shaoyong
Wang, Xiaolin
Hu, Jingying
Lv, Long
Xia, Caifen
Lu, Dai
Qin, Caiqin
author_sort Fu, Boqiao
collection PubMed
description Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of 8d is achieved through triggering apoptotic cell death.
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spelling pubmed-80746792021-05-09 Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer Fu, Boqiao Li, Yingjie Peng, Shaoyong Wang, Xiaolin Hu, Jingying Lv, Long Xia, Caifen Lu, Dai Qin, Caiqin R Soc Open Sci Chemistry Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of 8d is achieved through triggering apoptotic cell death. The Royal Society 2021-02-24 /pmc/articles/PMC8074679/ /pubmed/33972860 http://dx.doi.org/10.1098/rsos.201642 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Fu, Boqiao
Li, Yingjie
Peng, Shaoyong
Wang, Xiaolin
Hu, Jingying
Lv, Long
Xia, Caifen
Lu, Dai
Qin, Caiqin
Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title_full Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title_fullStr Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title_full_unstemmed Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title_short Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
title_sort synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074679/
https://www.ncbi.nlm.nih.gov/pubmed/33972860
http://dx.doi.org/10.1098/rsos.201642
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