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The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study

Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients wi...

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Autores principales: Lin, Jou-Yu, Tung, Che-Se, Wang, Jen-Chun, Chien, Wu-Chien, Chung, Chi-Hsiang, Lin, Chih-Yuan, Tsai, Shih-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074774/
https://www.ncbi.nlm.nih.gov/pubmed/33924263
http://dx.doi.org/10.3390/ijerph18084389
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author Lin, Jou-Yu
Tung, Che-Se
Wang, Jen-Chun
Chien, Wu-Chien
Chung, Chi-Hsiang
Lin, Chih-Yuan
Tsai, Shih-Hung
author_facet Lin, Jou-Yu
Tung, Che-Se
Wang, Jen-Chun
Chien, Wu-Chien
Chung, Chi-Hsiang
Lin, Chih-Yuan
Tsai, Shih-Hung
author_sort Lin, Jou-Yu
collection PubMed
description Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.
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spelling pubmed-80747742021-04-27 The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study Lin, Jou-Yu Tung, Che-Se Wang, Jen-Chun Chien, Wu-Chien Chung, Chi-Hsiang Lin, Chih-Yuan Tsai, Shih-Hung Int J Environ Res Public Health Article Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA. MDPI 2021-04-20 /pmc/articles/PMC8074774/ /pubmed/33924263 http://dx.doi.org/10.3390/ijerph18084389 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Jou-Yu
Tung, Che-Se
Wang, Jen-Chun
Chien, Wu-Chien
Chung, Chi-Hsiang
Lin, Chih-Yuan
Tsai, Shih-Hung
The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title_full The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title_fullStr The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title_full_unstemmed The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title_short The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study
title_sort association between migraine and abdominal aortic aneurysms: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074774/
https://www.ncbi.nlm.nih.gov/pubmed/33924263
http://dx.doi.org/10.3390/ijerph18084389
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