The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids

Binding behaviours between cyclopentanocucurbit[6]uril (CyP(6)Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP(6)Q[6] forms a 1 : 2 inclusion complex...

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Autores principales: Cheng, Siyuan, Zhao, Weiwei, Yang, Xinan, Meng, Ye, Wei, Liantong, Tao, Zhu, Ma, Peihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074881/
https://www.ncbi.nlm.nih.gov/pubmed/33959363
http://dx.doi.org/10.1098/rsos.202120
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author Cheng, Siyuan
Zhao, Weiwei
Yang, Xinan
Meng, Ye
Wei, Liantong
Tao, Zhu
Ma, Peihua
author_facet Cheng, Siyuan
Zhao, Weiwei
Yang, Xinan
Meng, Ye
Wei, Liantong
Tao, Zhu
Ma, Peihua
author_sort Cheng, Siyuan
collection PubMed
description Binding behaviours between cyclopentanocucurbit[6]uril (CyP(6)Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP(6)Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP(6)Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behaviour.
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spelling pubmed-80748812021-05-05 The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids Cheng, Siyuan Zhao, Weiwei Yang, Xinan Meng, Ye Wei, Liantong Tao, Zhu Ma, Peihua R Soc Open Sci Chemistry Binding behaviours between cyclopentanocucurbit[6]uril (CyP(6)Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP(6)Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP(6)Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behaviour. The Royal Society 2021-03-31 /pmc/articles/PMC8074881/ /pubmed/33959363 http://dx.doi.org/10.1098/rsos.202120 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Cheng, Siyuan
Zhao, Weiwei
Yang, Xinan
Meng, Ye
Wei, Liantong
Tao, Zhu
Ma, Peihua
The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title_full The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title_fullStr The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title_full_unstemmed The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title_short The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
title_sort binding behaviours between cyclopentanocucurbit[6]uril and three amino acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074881/
https://www.ncbi.nlm.nih.gov/pubmed/33959363
http://dx.doi.org/10.1098/rsos.202120
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