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Host-Diet Effect on the Metabolism of Bifidobacterium
Bifidobacterium has a diverse host range and shows several beneficial properties to the hosts. Many species should have co-evolved with their hosts, but the phylogeny of Bifidobacterium is dissimilar to that of host animals. The discrepancy could be linked to the niche-specific evolution due to host...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074910/ https://www.ncbi.nlm.nih.gov/pubmed/33924280 http://dx.doi.org/10.3390/genes12040609 |
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author | Satti, Maria Modesto, Monica Endo, Akihito Kawashima, Takeshi Mattarelli, Paola Arita, Masanori |
author_facet | Satti, Maria Modesto, Monica Endo, Akihito Kawashima, Takeshi Mattarelli, Paola Arita, Masanori |
author_sort | Satti, Maria |
collection | PubMed |
description | Bifidobacterium has a diverse host range and shows several beneficial properties to the hosts. Many species should have co-evolved with their hosts, but the phylogeny of Bifidobacterium is dissimilar to that of host animals. The discrepancy could be linked to the niche-specific evolution due to hosts’ dietary carbohydrates. We investigated the relationship between bifidobacteria and their host diet using a comparative genomics approach. Since carbohydrates are the main class of nutrients for bifidobacterial growth, we examined the distribution of carbohydrate-active enzymes, in particular glycoside hydrolases (GHs) that metabolize unique oligosaccharides. When bifidobacterial species are classified by their distribution of GH genes, five groups arose according to their hosts’ feeding behavior. The distribution of GH genes was only weakly associated with the phylogeny of the host animals or with genomic features such as genome size. Thus, the hosts’ dietary pattern is the key determinant of the distribution and evolution of GH genes. |
format | Online Article Text |
id | pubmed-8074910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80749102021-04-27 Host-Diet Effect on the Metabolism of Bifidobacterium Satti, Maria Modesto, Monica Endo, Akihito Kawashima, Takeshi Mattarelli, Paola Arita, Masanori Genes (Basel) Article Bifidobacterium has a diverse host range and shows several beneficial properties to the hosts. Many species should have co-evolved with their hosts, but the phylogeny of Bifidobacterium is dissimilar to that of host animals. The discrepancy could be linked to the niche-specific evolution due to hosts’ dietary carbohydrates. We investigated the relationship between bifidobacteria and their host diet using a comparative genomics approach. Since carbohydrates are the main class of nutrients for bifidobacterial growth, we examined the distribution of carbohydrate-active enzymes, in particular glycoside hydrolases (GHs) that metabolize unique oligosaccharides. When bifidobacterial species are classified by their distribution of GH genes, five groups arose according to their hosts’ feeding behavior. The distribution of GH genes was only weakly associated with the phylogeny of the host animals or with genomic features such as genome size. Thus, the hosts’ dietary pattern is the key determinant of the distribution and evolution of GH genes. MDPI 2021-04-20 /pmc/articles/PMC8074910/ /pubmed/33924280 http://dx.doi.org/10.3390/genes12040609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Satti, Maria Modesto, Monica Endo, Akihito Kawashima, Takeshi Mattarelli, Paola Arita, Masanori Host-Diet Effect on the Metabolism of Bifidobacterium |
title | Host-Diet Effect on the Metabolism of Bifidobacterium |
title_full | Host-Diet Effect on the Metabolism of Bifidobacterium |
title_fullStr | Host-Diet Effect on the Metabolism of Bifidobacterium |
title_full_unstemmed | Host-Diet Effect on the Metabolism of Bifidobacterium |
title_short | Host-Diet Effect on the Metabolism of Bifidobacterium |
title_sort | host-diet effect on the metabolism of bifidobacterium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074910/ https://www.ncbi.nlm.nih.gov/pubmed/33924280 http://dx.doi.org/10.3390/genes12040609 |
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