Cargando…
Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test
Reduced heart rate variability (HRV) and dysfunction of the autonomic nervous system (ANS) have been observed in schizophrenia patients. HRV parameters of schizophrenia patients in the resting state have been well-documented; however, these parameters of schizophrenia patients who experience continu...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074969/ https://www.ncbi.nlm.nih.gov/pubmed/33912081 http://dx.doi.org/10.3389/fpsyt.2021.626991 |
_version_ | 1783684459256610816 |
---|---|
author | Liu, Ya Huang, Yuanyuan Zhou, Jing Li, Guixiang Chen, Jun Xiang, Zhiming Wu, Fengchun Wu, Kai |
author_facet | Liu, Ya Huang, Yuanyuan Zhou, Jing Li, Guixiang Chen, Jun Xiang, Zhiming Wu, Fengchun Wu, Kai |
author_sort | Liu, Ya |
collection | PubMed |
description | Reduced heart rate variability (HRV) and dysfunction of the autonomic nervous system (ANS) have been observed in schizophrenia patients. HRV parameters of schizophrenia patients in the resting state have been well-documented; however, these parameters of schizophrenia patients who experience continuous psychophysiological stress remain unclear. The objective of this study was to systematically explore the linear and nonlinear HRV parameters between schizophrenia patients and normal controls and to detect the adaptive capabilities of HRV of schizophrenia patients during the stimulation tests of autonomic nervous system. Forty-five schizophrenia patients and forty-five normal controls, matched for age, sex and body mass index, completed a 14 min ANS test. Thirteen linear and nonlinear HRV parameters of all subjects under the ANS test were computed and statistically analyzed between groups and between sessions. The STROBE checklist was adhered to in this study. All time-domain HRV features in the ANS test were significantly different between schizophrenia patients and normal controls (p < 0.01). The schizophrenia patients showed significantly low values in the Poincaré indices, which revealed significantly decreased heart rate fluctuation complexity compared with that of normal controls (p < 0.001). In addition, the normal controls, not schizophrenia patients, showed significant differences between the recovery and stress states in the parameters of low frequency, high frequency, and nonlinear dynamics. Schizophrenia patients showed autonomic dysfunction of the heart in a series of stimulation tests of the autonomic nervous system and could not regain normal physiological functions after stress cessation. Our findings revealed that the dynamic parameters of HRV in psychophysiological stress are sensitive and practical for a diagnosis of schizophrenia. |
format | Online Article Text |
id | pubmed-8074969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80749692021-04-27 Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test Liu, Ya Huang, Yuanyuan Zhou, Jing Li, Guixiang Chen, Jun Xiang, Zhiming Wu, Fengchun Wu, Kai Front Psychiatry Psychiatry Reduced heart rate variability (HRV) and dysfunction of the autonomic nervous system (ANS) have been observed in schizophrenia patients. HRV parameters of schizophrenia patients in the resting state have been well-documented; however, these parameters of schizophrenia patients who experience continuous psychophysiological stress remain unclear. The objective of this study was to systematically explore the linear and nonlinear HRV parameters between schizophrenia patients and normal controls and to detect the adaptive capabilities of HRV of schizophrenia patients during the stimulation tests of autonomic nervous system. Forty-five schizophrenia patients and forty-five normal controls, matched for age, sex and body mass index, completed a 14 min ANS test. Thirteen linear and nonlinear HRV parameters of all subjects under the ANS test were computed and statistically analyzed between groups and between sessions. The STROBE checklist was adhered to in this study. All time-domain HRV features in the ANS test were significantly different between schizophrenia patients and normal controls (p < 0.01). The schizophrenia patients showed significantly low values in the Poincaré indices, which revealed significantly decreased heart rate fluctuation complexity compared with that of normal controls (p < 0.001). In addition, the normal controls, not schizophrenia patients, showed significant differences between the recovery and stress states in the parameters of low frequency, high frequency, and nonlinear dynamics. Schizophrenia patients showed autonomic dysfunction of the heart in a series of stimulation tests of the autonomic nervous system and could not regain normal physiological functions after stress cessation. Our findings revealed that the dynamic parameters of HRV in psychophysiological stress are sensitive and practical for a diagnosis of schizophrenia. Frontiers Media S.A. 2021-03-30 /pmc/articles/PMC8074969/ /pubmed/33912081 http://dx.doi.org/10.3389/fpsyt.2021.626991 Text en Copyright © 2021 Liu, Huang, Zhou, Li, Chen, Xiang, Wu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Liu, Ya Huang, Yuanyuan Zhou, Jing Li, Guixiang Chen, Jun Xiang, Zhiming Wu, Fengchun Wu, Kai Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title | Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title_full | Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title_fullStr | Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title_full_unstemmed | Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title_short | Altered Heart Rate Variability in Patients With Schizophrenia During an Autonomic Nervous Test |
title_sort | altered heart rate variability in patients with schizophrenia during an autonomic nervous test |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074969/ https://www.ncbi.nlm.nih.gov/pubmed/33912081 http://dx.doi.org/10.3389/fpsyt.2021.626991 |
work_keys_str_mv | AT liuya alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT huangyuanyuan alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT zhoujing alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT liguixiang alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT chenjun alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT xiangzhiming alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT wufengchun alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest AT wukai alteredheartratevariabilityinpatientswithschizophreniaduringanautonomicnervoustest |