Cargando…

Single-Cell Atlas Reveals Fatty Acid Metabolites Regulate the Functional Heterogeneity of Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (MSCs) are widely used clinically due to their versatile roles in multipotency, immunomodulation, and hematopoietic stem cell (HSC) niche function. However, cellular heterogeneity limits MSCs in the consistency and efficacy of their clinical applications. Metabolis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Jiayi, Lou, Qi, Zeng, Yunxin, Liang, Yingying, Xie, Siyu, Xu, Quanhui, Yuan, Lisha, Wang, Jin, Jiang, Linjia, Mou, Lisha, Lin, Dongjun, Zhao, Meng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075002/ https://www.ncbi.nlm.nih.gov/pubmed/33912565 http://dx.doi.org/10.3389/fcell.2021.653308

Ejemplares similares

Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma
por: Lou, Qi, et al.
Publicado: (2021)

Editorial: Targeting Heterogeneity of Mesenchymal Stem Cells
por: Zhang, Qi, et al.
Publicado: (2022)

miR-92a-3p Promoted EMT via Targeting LATS1 in Cervical Cancer Stem Cells
por: Liu, Shuangyue, et al.
Publicado: (2021)

Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow
por: Mabuchi, Yo, et al.
Publicado: (2021)

Cross-Tissue Characterization of Heterogeneities of Mesenchymal Stem Cells and Their Differentiation Potentials
por: Hou, Wenhong, et al.
Publicado: (2021)

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4(+) T Cell in Gastric Cancer
por: Yao, Fuwen, et al.
Publicado: (2021)

Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells
por: Yao, Fuwen, et al.
Publicado: (2022)

Corrigendum: Single-cell RNA sequencing reveals the role of phosphorylation-related genes in hepatocellular carcinoma stem cells
por: Yao, Fuwen, et al.
Publicado: (2023)

Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity
por: Wruck, Wasco, et al.
Publicado: (2021)

Cell senescence alters responses of porcine trabecular meshwork cells to shear stress
por: Du, Ruotian, et al.
Publicado: (2022)

Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
por: Fan, Siyu, et al.
Publicado: (2023)

Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation
por: Gao, Qianmin, et al.
Publicado: (2022)

Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications
por: Zhang, Juan, et al.
Publicado: (2021)

Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
por: Liu, Chang, et al.
Publicado: (2022)

The Small GTPases Rab27b Regulates Mitochondrial Fatty Acid Oxidative Metabolism of Cardiac Mesenchymal Stem Cells
por: Jin, Yue, et al.
Publicado: (2020)

Parabolic relationship between SMAD3 expression level and the reprogramming efficiency of goat induced mammary epithelial cells
por: Wu, Yulian, et al.
Publicado: (2022)

Dissecting the molecular trajectory of fibroblast reprogramming to chemically induced mammary epithelial cells
por: Qin, Liangshan, et al.
Publicado: (2023)

Asymmetric Cell Division and Tumor Heterogeneity
por: Li, Zizhu, et al.
Publicado: (2022)

Editorial: Functional heterogeneity of stem cells
por: Tyurin-Kuzmin, Pyotr A., et al.
Publicado: (2023)

CircRNA_100395 Carried by Exosomes From Adipose-Derived Mesenchymal Stem Cells Inhibits the Malignant Transformation of Non-Small Cell Lung Carcinoma Through the miR-141-3p-LATS2 Axis
por: Zhang, Chong, et al.
Publicado: (2021)

T Cell Membrane Heterogeneity Aids Antigen Recognition and T Cell Activation
por: Farrell, Megan V., et al.
Publicado: (2020)

Muscle satellite cell heterogeneity and self-renewal
por: Motohashi, Norio, et al.
Publicado: (2014)

Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development
por: Van Der Meulen, Kristyn L., et al.
Publicado: (2020)

Rapid direct conversion of bovine non-adipogenic fibroblasts into adipocyte-like cells by a small-molecule cocktail
por: Sun, Longfei, et al.
Publicado: (2023)

The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
por: Chen, Xiaoying, et al.
Publicado: (2022)

Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration
por: Zhou, Yiwen, et al.
Publicado: (2023)

Merits and challenges of iPSC-derived organoids for clinical applications
por: Xu, Ziran, et al.
Publicado: (2023)

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration
por: Lu, Lin, et al.
Publicado: (2022)

Transplantation to study satellite cell heterogeneity in skeletal muscle
por: Hekmatnejad, Bahareh, et al.
Publicado: (2022)

Reproductive and Developmental Toxicity Assessment of Human Umbilical Cord Mesenchymal Stem Cells in Rats
por: Li, Xiaobo, et al.
Publicado: (2022)

Computation of Single-Cell Metabolite Distributions Using Mixture Models
por: Tonn, Mona K., et al.
Publicado: (2020)

Exosomes Released From Human Bone Marrow–Derived Mesenchymal Stem Cell Attenuate Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation in Mice
por: Li, Ke-Liang, et al.
Publicado: (2021)

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung Adenocarcinoma
por: Wang, Youyu, et al.
Publicado: (2021)

Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis
por: Lin, Xinwei, et al.
Publicado: (2022)

Single cell analysis reveals satellite cell heterogeneity for proinflammatory chemokine expression
por: Andre, Alexander B., et al.
Publicado: (2023)

Mitochondrial heteroplasmy as a cause of cell-to-cell phenotypic heterogeneity in clonal populations
por: Knorre, Dmitry A.
Publicado: (2023)

Editorial: Yeast Differentiation: From Cell-to-Cell Heterogeneity to Replicative Aging and Regulated Cell Death
por: Hardwick, J. Marie, et al.
Publicado: (2022)

The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases
por: Xu, Binyue, et al.
Publicado: (2022)

Time-Dependent Internalization of S100B by Mesenchymal Stem Cells via the Pathways of Clathrin- and Lipid Raft-Mediated Endocytosis
por: Zhang, Ying, et al.
Publicado: (2021)

Exosomal miR-500 Derived From Lipopolysaccharide-Treated Macrophage Accelerates Liver Fibrosis by Suppressing MFN2
por: Chen, Lisha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_miepc771vaesfudkkpufsci5h9