Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms

Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with...

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Autores principales: Ghani, Rohma, Mullish, Benjamin H, McDonald, Julie A K, Ghazy, Anan, Williams, Horace R T, Brannigan, Eimear T, Mookerjee, Siddharth, Satta, Giovanni, Gilchrist, Mark, Duncan, Neill, Corbett, Richard, Innes, Andrew J, Pavlů, Jiří, Thursz, Mark R, Davies, Frances, Marchesi, Julian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075030/
https://www.ncbi.nlm.nih.gov/pubmed/32681643
http://dx.doi.org/10.1093/cid/ciaa948
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author Ghani, Rohma
Mullish, Benjamin H
McDonald, Julie A K
Ghazy, Anan
Williams, Horace R T
Brannigan, Eimear T
Mookerjee, Siddharth
Satta, Giovanni
Gilchrist, Mark
Duncan, Neill
Corbett, Richard
Innes, Andrew J
Pavlů, Jiří
Thursz, Mark R
Davies, Frances
Marchesi, Julian R
author_facet Ghani, Rohma
Mullish, Benjamin H
McDonald, Julie A K
Ghazy, Anan
Williams, Horace R T
Brannigan, Eimear T
Mookerjee, Siddharth
Satta, Giovanni
Gilchrist, Mark
Duncan, Neill
Corbett, Richard
Innes, Andrew J
Pavlů, Jiří
Thursz, Mark R
Davies, Frances
Marchesi, Julian R
author_sort Ghani, Rohma
collection PubMed
description Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
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spelling pubmed-80750302021-04-29 Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms Ghani, Rohma Mullish, Benjamin H McDonald, Julie A K Ghazy, Anan Williams, Horace R T Brannigan, Eimear T Mookerjee, Siddharth Satta, Giovanni Gilchrist, Mark Duncan, Neill Corbett, Richard Innes, Andrew J Pavlů, Jiří Thursz, Mark R Davies, Frances Marchesi, Julian R Clin Infect Dis Brief Reports Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates. Oxford University Press 2020-07-18 /pmc/articles/PMC8075030/ /pubmed/32681643 http://dx.doi.org/10.1093/cid/ciaa948 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Ghani, Rohma
Mullish, Benjamin H
McDonald, Julie A K
Ghazy, Anan
Williams, Horace R T
Brannigan, Eimear T
Mookerjee, Siddharth
Satta, Giovanni
Gilchrist, Mark
Duncan, Neill
Corbett, Richard
Innes, Andrew J
Pavlů, Jiří
Thursz, Mark R
Davies, Frances
Marchesi, Julian R
Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title_full Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title_fullStr Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title_full_unstemmed Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title_short Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
title_sort disease prevention not decolonization: a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075030/
https://www.ncbi.nlm.nih.gov/pubmed/32681643
http://dx.doi.org/10.1093/cid/ciaa948
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