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Dosage Adjustment of Irinotecan in Patients with UGT1A1 Polymorphisms: A Review of Current Literature

OBJECTIVE: To review available literature regarding pharmacogenomics (PGx) effects on the metabolism of irinotecan by the UGT1A1 gene and the resulting dose adjustments based on PGx genetic variant. SUMMARY: Irinotecan is a chemotherapy agent commonly used in treatment of various cancers such as met...

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Detalles Bibliográficos
Autores principales:	Argevani, Lia, Hughes, Caren, Schuh, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	University of Minnesota Libraries Publishing 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075136/ https://www.ncbi.nlm.nih.gov/pubmed/34007623 http://dx.doi.org/10.24926/iip.v11i3.3203

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