Cargando…

Farnesyl pyrophosphate is a new danger signal inducing acute cell death

Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce cell death, inflammation, and tissue damage. The mevalonate (MVA) pathway is an essential, highly conserved and dynamic metabolic pathway. Here, we discover...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jing, Zhang, Xiaochen, Li, Liping, Ma, Xianqiang, Yang, Chunxiao, Liu, Zhaodi, Li, Chenyang, Fernandez-Cabezudo, Maria J., al-Ramadi, Basel K., Wu, Chuan, Huang, Weishan, Zhang, Yong, Zhang, Yonghui, Liu, Wanli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075202/ https://www.ncbi.nlm.nih.gov/pubmed/33901180 http://dx.doi.org/10.1371/journal.pbio.3001134

Ejemplares similares

Correction: Farnesyl pyrophosphate is a new danger signal inducing acute cell death
por: Chen, Jing, et al.
Publicado: (2023)

Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase
por: Ohno, K, et al.
Publicado: (2011)

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii
por: Zhao, Yu-Jun, et al.
Publicado: (2015)

Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants
por: Qian, Jieying, et al.
Publicado: (2017)

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist
por: Goto, Tsuyoshi, et al.
Publicado: (2011)

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
por: Park, Jaeok, et al.
Publicado: (2017)

Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate
por: Li, Min, et al.
Publicado: (2020)

Distribution of Endogenous Farnesyl Pyrophosphate and Four Species of Lysophosphatidic Acid in Rodent Brain
por: Lee, Sung Ha, et al.
Publicado: (2010)

Lentiviral-Mediated Silencing of Farnesyl Pyrophosphate Synthase through RNA Interference in Mice
por: Yang, Jian, et al.
Publicado: (2015)

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
por: Park, Jaeok, et al.
Publicado: (2017)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
por: Park, Jaeok, et al.
Publicado: (2021)

Functional Characterization of the Xanthophyllomyces dendrorhous Farnesyl Pyrophosphate Synthase and Geranylgeranyl Pyrophosphate Synthase Encoding Genes That Are Involved in the Synthesis of Isoprenoid Precursors
por: Alcaíno, Jennifer, et al.
Publicado: (2014)

Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13
por: Lemfack, Marie Chantal, et al.
Publicado: (2021)

Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats
por: HAN, JIE, et al.
Publicado: (2016)

Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa
por: Schmidberger, Jason W., et al.
Publicado: (2015)

Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling
por: Zhao, Chen-Ze, et al.
Publicado: (2016)

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate
por: Park, Jaeok, et al.
Publicado: (2014)

Molecular characterization of farnesyl pyrophosphate synthase from Bacopa monniera by comparative modeling and docking studies
por: Vishwakarma, Rishi Kishore, et al.
Publicado: (2012)

Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera
por: Ferriols, Victor Marco Emmanuel N., et al.
Publicado: (2015)

Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production
por: Wichmann, Julian, et al.
Publicado: (2022)

Integration of Salmonella into Combination Cancer Therapy
por: Al-Saafeen, Besan H., et al.
Publicado: (2021)

Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment‐based lead discovery
por: Opassi, Giulia, et al.
Publicado: (2020)

Strengthening Triterpene Saponins Biosynthesis by Over-Expression of Farnesyl Pyrophosphate Synthase Gene and RNA Interference of Cycloartenol Synthase Gene in Panax notoginseng Cells
por: Yang, Yan, et al.
Publicado: (2017)

Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling
por: Han, Jie, et al.
Publicado: (2019)

Attenuated Bacteria as Immunotherapeutic Tools for Cancer Treatment
por: Kaimala, Suneesh, et al.
Publicado: (2018)

Functional analysis of Pogostemon cablin farnesyl pyrophosphate synthase gene and its binding transcription factor PcWRKY44 in regulating biosynthesis of patchouli alcohol
por: Wang, Xiaobing, et al.
Publicado: (2022)

Orexin-1 Receptor Co-Localizes with Pancreatic Hormones in Islet Cells and Modulates the Outcome of Streptozotocin-Induced Diabetes Mellitus
por: Adeghate, Ernest, et al.
Publicado: (2010)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants()
por: Tsoumpra, Maria K., et al.
Publicado: (2015)

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure
por: Park, Jaeok, et al.
Publicado: (2012)

Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model
por: Fernandez-Cabezudo, Maria J., et al.
Publicado: (2013)

Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism
por: George, Junu A., et al.
Publicado: (2016)

The Immunomodulatory Effects of Honey and Associated Flavonoids in Cancer
por: Masad, Razan J., et al.
Publicado: (2021)

An Essential Farnesylated Kinesin in Trypanosoma brucei
por: Engelson, Erin J., et al.
Publicado: (2011)

Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer
por: Al-Saafeen, Besan H., et al.
Publicado: (2022)

Lactic Acid Bacteria Isolated from Fresh Vegetable Products: Potential Probiotic and Postbiotic Characteristics Including Immunomodulatory Effects
por: Alameri, Fatima, et al.
Publicado: (2022)

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase in Toxoplasma gondii
por: Yang, Xuke, et al.
Publicado: (2022)

The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells
por: Aryappalli, Priyanka, et al.
Publicado: (2017)

PEG-Farnesyl Thiosalicylic Acid Telodendrimer Micelles as an Improved Formulation for Targeted Delivery of Paclitaxel
por: Zhang, Xiaolan, et al.
Publicado: (2014)

Pyrophosphate of Iron
por: Nichols, James R.
Publicado: (1862)

Cannot write session to /tmp/vufind_sessions/sess_p8305vlmqk313n58bnafknd2ms