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Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers

This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic difference...

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Autores principales: Ho, Peh Joo, Yeoh, Yen Shing, Miao, Hui, Lim, Swee Ho, Tan, Ern Yu, Tan, Benita Kiat Tee, Tan, Veronique Kiak Mien, Tan, Su Ming, Yong, Wei Sean, Wong, Fuh Yong, Madhukumar, Preetha, Chan, Ching Wan, Iau, Philip Tsau Choong, Lee, Soo Chin, Putti, Thomas, Buhari, Shaik Ahmad, Lee, Jin Yee, Lim, Geok Hoon, Woo, Evan, Yan, Zhiyan, Chan, Patrick Mun Yew, Chen, Juliana Jia Chuan, Lu, Sarah Qinghui, Dent, Rebecca, Lee, Wai Peng, Mok, Chi Wei, Seah, Jaime Chin Mui, Sim, Xueling, van Dam, Rob Martinus, Chia, Kee Seng, Li, Jingmei, Hartman, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075208/
https://www.ncbi.nlm.nih.gov/pubmed/33901219
http://dx.doi.org/10.1371/journal.pone.0250102
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author Ho, Peh Joo
Yeoh, Yen Shing
Miao, Hui
Lim, Swee Ho
Tan, Ern Yu
Tan, Benita Kiat Tee
Tan, Veronique Kiak Mien
Tan, Su Ming
Yong, Wei Sean
Wong, Fuh Yong
Madhukumar, Preetha
Chan, Ching Wan
Iau, Philip Tsau Choong
Lee, Soo Chin
Putti, Thomas
Buhari, Shaik Ahmad
Lee, Jin Yee
Lim, Geok Hoon
Woo, Evan
Yan, Zhiyan
Chan, Patrick Mun Yew
Chen, Juliana Jia Chuan
Lu, Sarah Qinghui
Dent, Rebecca
Lee, Wai Peng
Mok, Chi Wei
Seah, Jaime Chin Mui
Sim, Xueling
van Dam, Rob Martinus
Chia, Kee Seng
Li, Jingmei
Hartman, Mikael
author_facet Ho, Peh Joo
Yeoh, Yen Shing
Miao, Hui
Lim, Swee Ho
Tan, Ern Yu
Tan, Benita Kiat Tee
Tan, Veronique Kiak Mien
Tan, Su Ming
Yong, Wei Sean
Wong, Fuh Yong
Madhukumar, Preetha
Chan, Ching Wan
Iau, Philip Tsau Choong
Lee, Soo Chin
Putti, Thomas
Buhari, Shaik Ahmad
Lee, Jin Yee
Lim, Geok Hoon
Woo, Evan
Yan, Zhiyan
Chan, Patrick Mun Yew
Chen, Juliana Jia Chuan
Lu, Sarah Qinghui
Dent, Rebecca
Lee, Wai Peng
Mok, Chi Wei
Seah, Jaime Chin Mui
Sim, Xueling
van Dam, Rob Martinus
Chia, Kee Seng
Li, Jingmei
Hartman, Mikael
author_sort Ho, Peh Joo
collection PubMed
description This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers.
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spelling pubmed-80752082021-05-05 Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers Ho, Peh Joo Yeoh, Yen Shing Miao, Hui Lim, Swee Ho Tan, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Yong, Wei Sean Wong, Fuh Yong Madhukumar, Preetha Chan, Ching Wan Iau, Philip Tsau Choong Lee, Soo Chin Putti, Thomas Buhari, Shaik Ahmad Lee, Jin Yee Lim, Geok Hoon Woo, Evan Yan, Zhiyan Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Lu, Sarah Qinghui Dent, Rebecca Lee, Wai Peng Mok, Chi Wei Seah, Jaime Chin Mui Sim, Xueling van Dam, Rob Martinus Chia, Kee Seng Li, Jingmei Hartman, Mikael PLoS One Research Article This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers. Public Library of Science 2021-04-26 /pmc/articles/PMC8075208/ /pubmed/33901219 http://dx.doi.org/10.1371/journal.pone.0250102 Text en © 2021 Ho et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ho, Peh Joo
Yeoh, Yen Shing
Miao, Hui
Lim, Swee Ho
Tan, Ern Yu
Tan, Benita Kiat Tee
Tan, Veronique Kiak Mien
Tan, Su Ming
Yong, Wei Sean
Wong, Fuh Yong
Madhukumar, Preetha
Chan, Ching Wan
Iau, Philip Tsau Choong
Lee, Soo Chin
Putti, Thomas
Buhari, Shaik Ahmad
Lee, Jin Yee
Lim, Geok Hoon
Woo, Evan
Yan, Zhiyan
Chan, Patrick Mun Yew
Chen, Juliana Jia Chuan
Lu, Sarah Qinghui
Dent, Rebecca
Lee, Wai Peng
Mok, Chi Wei
Seah, Jaime Chin Mui
Sim, Xueling
van Dam, Rob Martinus
Chia, Kee Seng
Li, Jingmei
Hartman, Mikael
Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title_full Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title_fullStr Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title_full_unstemmed Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title_short Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
title_sort cohort profile: the singapore breast cancer cohort (sgbcc), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075208/
https://www.ncbi.nlm.nih.gov/pubmed/33901219
http://dx.doi.org/10.1371/journal.pone.0250102
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