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Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic difference...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075208/ https://www.ncbi.nlm.nih.gov/pubmed/33901219 http://dx.doi.org/10.1371/journal.pone.0250102 |
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author | Ho, Peh Joo Yeoh, Yen Shing Miao, Hui Lim, Swee Ho Tan, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Yong, Wei Sean Wong, Fuh Yong Madhukumar, Preetha Chan, Ching Wan Iau, Philip Tsau Choong Lee, Soo Chin Putti, Thomas Buhari, Shaik Ahmad Lee, Jin Yee Lim, Geok Hoon Woo, Evan Yan, Zhiyan Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Lu, Sarah Qinghui Dent, Rebecca Lee, Wai Peng Mok, Chi Wei Seah, Jaime Chin Mui Sim, Xueling van Dam, Rob Martinus Chia, Kee Seng Li, Jingmei Hartman, Mikael |
author_facet | Ho, Peh Joo Yeoh, Yen Shing Miao, Hui Lim, Swee Ho Tan, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Yong, Wei Sean Wong, Fuh Yong Madhukumar, Preetha Chan, Ching Wan Iau, Philip Tsau Choong Lee, Soo Chin Putti, Thomas Buhari, Shaik Ahmad Lee, Jin Yee Lim, Geok Hoon Woo, Evan Yan, Zhiyan Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Lu, Sarah Qinghui Dent, Rebecca Lee, Wai Peng Mok, Chi Wei Seah, Jaime Chin Mui Sim, Xueling van Dam, Rob Martinus Chia, Kee Seng Li, Jingmei Hartman, Mikael |
author_sort | Ho, Peh Joo |
collection | PubMed |
description | This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers. |
format | Online Article Text |
id | pubmed-8075208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80752082021-05-05 Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers Ho, Peh Joo Yeoh, Yen Shing Miao, Hui Lim, Swee Ho Tan, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Yong, Wei Sean Wong, Fuh Yong Madhukumar, Preetha Chan, Ching Wan Iau, Philip Tsau Choong Lee, Soo Chin Putti, Thomas Buhari, Shaik Ahmad Lee, Jin Yee Lim, Geok Hoon Woo, Evan Yan, Zhiyan Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Lu, Sarah Qinghui Dent, Rebecca Lee, Wai Peng Mok, Chi Wei Seah, Jaime Chin Mui Sim, Xueling van Dam, Rob Martinus Chia, Kee Seng Li, Jingmei Hartman, Mikael PLoS One Research Article This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers. Public Library of Science 2021-04-26 /pmc/articles/PMC8075208/ /pubmed/33901219 http://dx.doi.org/10.1371/journal.pone.0250102 Text en © 2021 Ho et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ho, Peh Joo Yeoh, Yen Shing Miao, Hui Lim, Swee Ho Tan, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Yong, Wei Sean Wong, Fuh Yong Madhukumar, Preetha Chan, Ching Wan Iau, Philip Tsau Choong Lee, Soo Chin Putti, Thomas Buhari, Shaik Ahmad Lee, Jin Yee Lim, Geok Hoon Woo, Evan Yan, Zhiyan Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Lu, Sarah Qinghui Dent, Rebecca Lee, Wai Peng Mok, Chi Wei Seah, Jaime Chin Mui Sim, Xueling van Dam, Rob Martinus Chia, Kee Seng Li, Jingmei Hartman, Mikael Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title | Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title_full | Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title_fullStr | Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title_full_unstemmed | Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title_short | Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
title_sort | cohort profile: the singapore breast cancer cohort (sgbcc), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075208/ https://www.ncbi.nlm.nih.gov/pubmed/33901219 http://dx.doi.org/10.1371/journal.pone.0250102 |
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