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Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country

A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in sout...

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Autores principales: Pan, Yi-Hua, Liao, Mei-Ying, Chien, Yu-Wen, Ho, Tzong-Shiann, Ko, Hui-Ying, Yang, Chin-Rur, Chang, Shu-Fen, Yu, Chia-Yi, Lin, Shu-Yu, Shih, Pin-Wei, Shu, Pei-Yun, Chao, Day-Yu, Pan, Chao-Ying, Chen, Hong-Ming, Perng, Guey-Chuen, Ku, Chia-Chi, King, Chwan-Chuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075253/
https://www.ncbi.nlm.nih.gov/pubmed/33793562
http://dx.doi.org/10.1371/journal.pntd.0009312
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author Pan, Yi-Hua
Liao, Mei-Ying
Chien, Yu-Wen
Ho, Tzong-Shiann
Ko, Hui-Ying
Yang, Chin-Rur
Chang, Shu-Fen
Yu, Chia-Yi
Lin, Shu-Yu
Shih, Pin-Wei
Shu, Pei-Yun
Chao, Day-Yu
Pan, Chao-Ying
Chen, Hong-Ming
Perng, Guey-Chuen
Ku, Chia-Chi
King, Chwan-Chuen
author_facet Pan, Yi-Hua
Liao, Mei-Ying
Chien, Yu-Wen
Ho, Tzong-Shiann
Ko, Hui-Ying
Yang, Chin-Rur
Chang, Shu-Fen
Yu, Chia-Yi
Lin, Shu-Yu
Shih, Pin-Wei
Shu, Pei-Yun
Chao, Day-Yu
Pan, Chao-Ying
Chen, Hong-Ming
Perng, Guey-Chuen
Ku, Chia-Chi
King, Chwan-Chuen
author_sort Pan, Yi-Hua
collection PubMed
description A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in southern Taiwan in 2015, we screened 1498 and 2603 serum samples from healthy residents aged ≥ 40 years in Kaohsiung City and Tainan City, respectively, to assess the seroprevalence of anti-DENV IgG in 2016. Seropositive samples were verified to exclude cross-reaction from Japanese encephalitis virus (JEV), using DENV/JEV-NS1 indirect IgG ELISA. We further identified viral serotypes and secondary DENV infections among positive samples in the two cities. The overall age-standardized seroprevalence of DENV-IgG among participants was 25.77% in Kaohsiung and 11.40% in Tainan, and the seroprevalence was significantly higher in older age groups of both cities. Although the percentages of secondary DENV infection in Kaohsiung and Tainan were very similar (43.09% and 44.76%, respectively), DENV-1 and DENV-2 spanned a wider age range in Kaohsiung, whereas DENV-2 was dominant in Tainan. As very few studies have obtained the serostatus of DENV infection in older adults and the elderly, this study highlights the need for further investigation into antibody status, as well as the safety and efficacy of dengue vaccination in these older populations.
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spelling pubmed-80752532021-05-05 Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country Pan, Yi-Hua Liao, Mei-Ying Chien, Yu-Wen Ho, Tzong-Shiann Ko, Hui-Ying Yang, Chin-Rur Chang, Shu-Fen Yu, Chia-Yi Lin, Shu-Yu Shih, Pin-Wei Shu, Pei-Yun Chao, Day-Yu Pan, Chao-Ying Chen, Hong-Ming Perng, Guey-Chuen Ku, Chia-Chi King, Chwan-Chuen PLoS Negl Trop Dis Research Article A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in southern Taiwan in 2015, we screened 1498 and 2603 serum samples from healthy residents aged ≥ 40 years in Kaohsiung City and Tainan City, respectively, to assess the seroprevalence of anti-DENV IgG in 2016. Seropositive samples were verified to exclude cross-reaction from Japanese encephalitis virus (JEV), using DENV/JEV-NS1 indirect IgG ELISA. We further identified viral serotypes and secondary DENV infections among positive samples in the two cities. The overall age-standardized seroprevalence of DENV-IgG among participants was 25.77% in Kaohsiung and 11.40% in Tainan, and the seroprevalence was significantly higher in older age groups of both cities. Although the percentages of secondary DENV infection in Kaohsiung and Tainan were very similar (43.09% and 44.76%, respectively), DENV-1 and DENV-2 spanned a wider age range in Kaohsiung, whereas DENV-2 was dominant in Tainan. As very few studies have obtained the serostatus of DENV infection in older adults and the elderly, this study highlights the need for further investigation into antibody status, as well as the safety and efficacy of dengue vaccination in these older populations. Public Library of Science 2021-04-01 /pmc/articles/PMC8075253/ /pubmed/33793562 http://dx.doi.org/10.1371/journal.pntd.0009312 Text en © 2021 Pan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pan, Yi-Hua
Liao, Mei-Ying
Chien, Yu-Wen
Ho, Tzong-Shiann
Ko, Hui-Ying
Yang, Chin-Rur
Chang, Shu-Fen
Yu, Chia-Yi
Lin, Shu-Yu
Shih, Pin-Wei
Shu, Pei-Yun
Chao, Day-Yu
Pan, Chao-Ying
Chen, Hong-Ming
Perng, Guey-Chuen
Ku, Chia-Chi
King, Chwan-Chuen
Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title_full Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title_fullStr Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title_full_unstemmed Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title_short Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
title_sort use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075253/
https://www.ncbi.nlm.nih.gov/pubmed/33793562
http://dx.doi.org/10.1371/journal.pntd.0009312
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