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The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

Centriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. Key to this is the regulated degradation of PLK4, the master regulator of centriole duplication. Here, we show that the Rac1 guanine nucleotide exchange factor (GEF) Tiam1 localises to centrosome...

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Detalles Bibliográficos
Autores principales:	Porter, Andrew P., Reed, Hannah, White, Gavin R. M., Ogg, Erinn-Lee, Whalley, Helen J., Malliri, Angeliki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075378/ https://www.ncbi.nlm.nih.gov/pubmed/33758078 http://dx.doi.org/10.1242/jcs.252502

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