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Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are sm...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto de Medicina Tropical
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075620/ https://www.ncbi.nlm.nih.gov/pubmed/33909847 http://dx.doi.org/10.1590/S1678-9946202163033 |
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author | Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Pires, Roberto da Justa Daher, Elizabeth De Francesco |
author_facet | Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Pires, Roberto da Justa Daher, Elizabeth De Francesco |
author_sort | Cavalcante, Malena Gadelha |
collection | PubMed |
description | HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis. |
format | Online Article Text |
id | pubmed-8075620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Instituto de Medicina Tropical |
record_format | MEDLINE/PubMed |
spelling | pubmed-80756202021-05-13 Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Pires, Roberto da Justa Daher, Elizabeth De Francesco Rev Inst Med Trop Sao Paulo Original Article HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis. Instituto de Medicina Tropical 2021-04-23 /pmc/articles/PMC8075620/ /pubmed/33909847 http://dx.doi.org/10.1590/S1678-9946202163033 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Pires, Roberto da Justa Daher, Elizabeth De Francesco Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title | Death-related factors in HIV/AIDS patients undergoing hemodialysis in
an intensive care unit |
title_full | Death-related factors in HIV/AIDS patients undergoing hemodialysis in
an intensive care unit |
title_fullStr | Death-related factors in HIV/AIDS patients undergoing hemodialysis in
an intensive care unit |
title_full_unstemmed | Death-related factors in HIV/AIDS patients undergoing hemodialysis in
an intensive care unit |
title_short | Death-related factors in HIV/AIDS patients undergoing hemodialysis in
an intensive care unit |
title_sort | death-related factors in hiv/aids patients undergoing hemodialysis in
an intensive care unit |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075620/ https://www.ncbi.nlm.nih.gov/pubmed/33909847 http://dx.doi.org/10.1590/S1678-9946202163033 |
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