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Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit

HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are sm...

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Autores principales: Cavalcante, Malena Gadelha, Parente, Matheus de Sá Roriz, Gomes, Pedro Eduardo Andrade de Carvalho, Meneses, Gdayllon Cavalcante, da Silva, Geraldo Bezerra, Pires, Roberto da Justa, Daher, Elizabeth De Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075620/
https://www.ncbi.nlm.nih.gov/pubmed/33909847
http://dx.doi.org/10.1590/S1678-9946202163033
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author Cavalcante, Malena Gadelha
Parente, Matheus de Sá Roriz
Gomes, Pedro Eduardo Andrade de Carvalho
Meneses, Gdayllon Cavalcante
da Silva, Geraldo Bezerra
Pires, Roberto da Justa
Daher, Elizabeth De Francesco
author_facet Cavalcante, Malena Gadelha
Parente, Matheus de Sá Roriz
Gomes, Pedro Eduardo Andrade de Carvalho
Meneses, Gdayllon Cavalcante
da Silva, Geraldo Bezerra
Pires, Roberto da Justa
Daher, Elizabeth De Francesco
author_sort Cavalcante, Malena Gadelha
collection PubMed
description HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis.
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spelling pubmed-80756202021-05-13 Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Pires, Roberto da Justa Daher, Elizabeth De Francesco Rev Inst Med Trop Sao Paulo Original Article HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis. Instituto de Medicina Tropical 2021-04-23 /pmc/articles/PMC8075620/ /pubmed/33909847 http://dx.doi.org/10.1590/S1678-9946202163033 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cavalcante, Malena Gadelha
Parente, Matheus de Sá Roriz
Gomes, Pedro Eduardo Andrade de Carvalho
Meneses, Gdayllon Cavalcante
da Silva, Geraldo Bezerra
Pires, Roberto da Justa
Daher, Elizabeth De Francesco
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title_full Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title_fullStr Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title_full_unstemmed Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title_short Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
title_sort death-related factors in hiv/aids patients undergoing hemodialysis in an intensive care unit
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075620/
https://www.ncbi.nlm.nih.gov/pubmed/33909847
http://dx.doi.org/10.1590/S1678-9946202163033
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