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Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors

Background  Borderline ovarian tumors (BOTs) are an intermediate form of neoplasia, between benign and malignant. The aim of this retrospective analysis is to evaluate the clinicopathological characteristic profile of BOTs and to determine the predictors of recurrence in BOTs. Methods  A retrospecti...

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Autores principales: Ifthikar, Mariam Anjum, Rajanbabu, Anupama, Nair, Indu R., Murali, Vinita, Nair, Anjaly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075629/
https://www.ncbi.nlm.nih.gov/pubmed/33937140
http://dx.doi.org/10.1055/s-0040-1721192
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author Ifthikar, Mariam Anjum
Rajanbabu, Anupama
Nair, Indu R.
Murali, Vinita
Nair, Anjaly S.
author_facet Ifthikar, Mariam Anjum
Rajanbabu, Anupama
Nair, Indu R.
Murali, Vinita
Nair, Anjaly S.
author_sort Ifthikar, Mariam Anjum
collection PubMed
description Background  Borderline ovarian tumors (BOTs) are an intermediate form of neoplasia, between benign and malignant. The aim of this retrospective analysis is to evaluate the clinicopathological characteristic profile of BOTs and to determine the predictors of recurrence in BOTs. Methods  A retrospective review of all patients diagnosed, treated, and followed up for BOTs between 2010 and 2017 at Amrita Institute of Medical Sciences, Kerala, India, was conducted. Clinicopathological details and details of management, outcome, and survival were retrieved, and data were analyzed descriptively and for survival. Results  A total of 103 patients were identified. During the median follow-up of 46.0 months, 15 (14.6%) patients developed recurrent disease, 6 (5.82%) had recurrence with progression to invasive carcinoma, and 9 had recurrent disease with borderline or benign histology. Mucinous tumors were found to have more recurrences than serous BOT (17.8 vs. 12.3%). Disease-related deaths (5/103 [4.9%]) were observed only in patients with progression to invasive carcinoma. Univariate analysis indicated that staging surgery was the most important prognostic factor that affected the disease-free survival ([DFS] 103 vs. 97 vs. 71 months, respectively, for complete staging vs. fertility-preserving staging vs. conservative surgery; p < 0.05). Conclusions  Conservative surgery was associated with a higher risk of recurrence. Fertility-preserving staging surgery is an acceptable option in younger patients. The overall survival is not affected by the mode of surgery.
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spelling pubmed-80756292021-04-29 Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors Ifthikar, Mariam Anjum Rajanbabu, Anupama Nair, Indu R. Murali, Vinita Nair, Anjaly S. South Asian J Cancer Background  Borderline ovarian tumors (BOTs) are an intermediate form of neoplasia, between benign and malignant. The aim of this retrospective analysis is to evaluate the clinicopathological characteristic profile of BOTs and to determine the predictors of recurrence in BOTs. Methods  A retrospective review of all patients diagnosed, treated, and followed up for BOTs between 2010 and 2017 at Amrita Institute of Medical Sciences, Kerala, India, was conducted. Clinicopathological details and details of management, outcome, and survival were retrieved, and data were analyzed descriptively and for survival. Results  A total of 103 patients were identified. During the median follow-up of 46.0 months, 15 (14.6%) patients developed recurrent disease, 6 (5.82%) had recurrence with progression to invasive carcinoma, and 9 had recurrent disease with borderline or benign histology. Mucinous tumors were found to have more recurrences than serous BOT (17.8 vs. 12.3%). Disease-related deaths (5/103 [4.9%]) were observed only in patients with progression to invasive carcinoma. Univariate analysis indicated that staging surgery was the most important prognostic factor that affected the disease-free survival ([DFS] 103 vs. 97 vs. 71 months, respectively, for complete staging vs. fertility-preserving staging vs. conservative surgery; p < 0.05). Conclusions  Conservative surgery was associated with a higher risk of recurrence. Fertility-preserving staging surgery is an acceptable option in younger patients. The overall survival is not affected by the mode of surgery. Thieme Medical and Scientific Publishers Pvt. Ltd. 2020-07 2021-03-19 /pmc/articles/PMC8075629/ /pubmed/33937140 http://dx.doi.org/10.1055/s-0040-1721192 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Ifthikar, Mariam Anjum
Rajanbabu, Anupama
Nair, Indu R.
Murali, Vinita
Nair, Anjaly S.
Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title_full Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title_fullStr Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title_full_unstemmed Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title_short Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors
title_sort retrospective analysis of factors affecting recurrence in borderline ovarian tumors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075629/
https://www.ncbi.nlm.nih.gov/pubmed/33937140
http://dx.doi.org/10.1055/s-0040-1721192
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