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Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling

Glioma is the most common brain tumor and is characterized by high mortality rates, high recurrence rates, and short survival time. Migration and invasion are the basic features of gliomas. Thus, inhibition of migration and invasion may be beneficial for the treatment of patients with glioma. Due to...

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Detalles Bibliográficos
Autores principales: Qu, Liangchen, Lin, Pan, Lin, Minjie, Ye, Shumin, Papa Akuetteh, Percy David, Youyou Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075667/
https://www.ncbi.nlm.nih.gov/pubmed/33959183
http://dx.doi.org/10.1155/2021/5540139
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author Qu, Liangchen
Lin, Pan
Lin, Minjie
Ye, Shumin
Papa Akuetteh, Percy David
Youyou Zhu,
author_facet Qu, Liangchen
Lin, Pan
Lin, Minjie
Ye, Shumin
Papa Akuetteh, Percy David
Youyou Zhu,
author_sort Qu, Liangchen
collection PubMed
description Glioma is the most common brain tumor and is characterized by high mortality rates, high recurrence rates, and short survival time. Migration and invasion are the basic features of gliomas. Thus, inhibition of migration and invasion may be beneficial for the treatment of patients with glioma. Due to its antitumor activity and chemical reactivity, fraxetin has attracted extensive interest and has been proven to be an effective antitumor agent in various cancer types. However, currently, the potential effects of fraxetin on glioma have not been investigated. Here, we demonstrate that fraxetin can inhibit the proliferation, invasion, and migration of glioma and induce apoptosis of glioma cells in vitro and in vivo. Therefore, these findings establish fraxetin as a drug candidate for glioma treatment. Furthermore, fraxetin was able to effectively inhibit the JAK2/STAT3 signaling in glioma. In summary, our results show that fraxetin inhibits proliferation, invasion, and migration of glioma by inhibiting JAK2/STAT3 signaling and inducing apoptosis of glioma cells. The present study provides a solid basis for the development of new glioma therapies.
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spelling pubmed-80756672021-05-05 Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling Qu, Liangchen Lin, Pan Lin, Minjie Ye, Shumin Papa Akuetteh, Percy David Youyou Zhu, Evid Based Complement Alternat Med Research Article Glioma is the most common brain tumor and is characterized by high mortality rates, high recurrence rates, and short survival time. Migration and invasion are the basic features of gliomas. Thus, inhibition of migration and invasion may be beneficial for the treatment of patients with glioma. Due to its antitumor activity and chemical reactivity, fraxetin has attracted extensive interest and has been proven to be an effective antitumor agent in various cancer types. However, currently, the potential effects of fraxetin on glioma have not been investigated. Here, we demonstrate that fraxetin can inhibit the proliferation, invasion, and migration of glioma and induce apoptosis of glioma cells in vitro and in vivo. Therefore, these findings establish fraxetin as a drug candidate for glioma treatment. Furthermore, fraxetin was able to effectively inhibit the JAK2/STAT3 signaling in glioma. In summary, our results show that fraxetin inhibits proliferation, invasion, and migration of glioma by inhibiting JAK2/STAT3 signaling and inducing apoptosis of glioma cells. The present study provides a solid basis for the development of new glioma therapies. Hindawi 2021-04-16 /pmc/articles/PMC8075667/ /pubmed/33959183 http://dx.doi.org/10.1155/2021/5540139 Text en Copyright © 2021 Liangchen Qu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qu, Liangchen
Lin, Pan
Lin, Minjie
Ye, Shumin
Papa Akuetteh, Percy David
Youyou Zhu,
Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title_full Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title_fullStr Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title_full_unstemmed Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title_short Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
title_sort fraxetin inhibits the proliferation and metastasis of glioma cells by inactivating jak2/stat3 signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075667/
https://www.ncbi.nlm.nih.gov/pubmed/33959183
http://dx.doi.org/10.1155/2021/5540139
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