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Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019

BACKGROUND: The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with...

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Autores principales: Yamaya, Takafumi, Hagiwara, Eri, Baba, Tomohisa, Kitayama, Takaaki, Murohashi, Kota, Higa, Katsuyuki, Sato, Yozo, Otoshi, Ryota, Tabata, Erina, Shintani, Ryota, Okabayashi, Hiroko, Ikeda, Satoshi, Niwa, Takashi, Nakazawa, Atsuhito, Oda, Tsuneyuki, Okuda, Ryo, Sekine, Akimasa, Kitamura, Hideya, Komatsu, Shigeru, Ogura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. on behalf of The Japanese Respiratory Society. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075813/
https://www.ncbi.nlm.nih.gov/pubmed/33965361
http://dx.doi.org/10.1016/j.resinv.2021.04.002
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author Yamaya, Takafumi
Hagiwara, Eri
Baba, Tomohisa
Kitayama, Takaaki
Murohashi, Kota
Higa, Katsuyuki
Sato, Yozo
Otoshi, Ryota
Tabata, Erina
Shintani, Ryota
Okabayashi, Hiroko
Ikeda, Satoshi
Niwa, Takashi
Nakazawa, Atsuhito
Oda, Tsuneyuki
Okuda, Ryo
Sekine, Akimasa
Kitamura, Hideya
Komatsu, Shigeru
Ogura, Takashi
author_facet Yamaya, Takafumi
Hagiwara, Eri
Baba, Tomohisa
Kitayama, Takaaki
Murohashi, Kota
Higa, Katsuyuki
Sato, Yozo
Otoshi, Ryota
Tabata, Erina
Shintani, Ryota
Okabayashi, Hiroko
Ikeda, Satoshi
Niwa, Takashi
Nakazawa, Atsuhito
Oda, Tsuneyuki
Okuda, Ryo
Sekine, Akimasa
Kitamura, Hideya
Komatsu, Shigeru
Ogura, Takashi
author_sort Yamaya, Takafumi
collection PubMed
description BACKGROUND: The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with mortality and severity in patients with COVID-19. METHODS: Among 361 Japanese patients with COVID-19 who were hospitalized at Kanagawa Cardiovascular and Respiratory Center between February 2020 and December 2020, 356 patients with data on serum KL-6 levels were enrolled and their medical records were retrospectively analyzed. RESULTS: A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission. The KL-6 levels on admission and the maximal KL-6 levels were higher in patients with severe disease (n = 60) than in those with nonsevere disease (n = 296). Furthermore, the maximal KL-6 levels were higher in nonsurvivors (n = 6) than in survivors (n = 350). In nonsurvivors, the KL-6 levels increased as the disease progressed. The optimal cutoff value of the maximal KL-6 level for discriminating between survivors and nonsurvivors was 684 U/mL, with a sensitivity of 83.3%, a specificity of 90.5%, and an area under the curve of 0.89. CONCLUSIONS: The serum KL-6 level was associated with disease severity. Patients with KL-6 levels ≥684 U/mL had a significantly poorer outcome than those with KL-6 levels <684 U/mL.
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spelling pubmed-80758132021-04-27 Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019 Yamaya, Takafumi Hagiwara, Eri Baba, Tomohisa Kitayama, Takaaki Murohashi, Kota Higa, Katsuyuki Sato, Yozo Otoshi, Ryota Tabata, Erina Shintani, Ryota Okabayashi, Hiroko Ikeda, Satoshi Niwa, Takashi Nakazawa, Atsuhito Oda, Tsuneyuki Okuda, Ryo Sekine, Akimasa Kitamura, Hideya Komatsu, Shigeru Ogura, Takashi Respir Investig Original Article BACKGROUND: The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with mortality and severity in patients with COVID-19. METHODS: Among 361 Japanese patients with COVID-19 who were hospitalized at Kanagawa Cardiovascular and Respiratory Center between February 2020 and December 2020, 356 patients with data on serum KL-6 levels were enrolled and their medical records were retrospectively analyzed. RESULTS: A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission. The KL-6 levels on admission and the maximal KL-6 levels were higher in patients with severe disease (n = 60) than in those with nonsevere disease (n = 296). Furthermore, the maximal KL-6 levels were higher in nonsurvivors (n = 6) than in survivors (n = 350). In nonsurvivors, the KL-6 levels increased as the disease progressed. The optimal cutoff value of the maximal KL-6 level for discriminating between survivors and nonsurvivors was 684 U/mL, with a sensitivity of 83.3%, a specificity of 90.5%, and an area under the curve of 0.89. CONCLUSIONS: The serum KL-6 level was associated with disease severity. Patients with KL-6 levels ≥684 U/mL had a significantly poorer outcome than those with KL-6 levels <684 U/mL. Published by Elsevier B.V. on behalf of The Japanese Respiratory Society. 2021-09 2021-04-27 /pmc/articles/PMC8075813/ /pubmed/33965361 http://dx.doi.org/10.1016/j.resinv.2021.04.002 Text en © 2021 Published by Elsevier B.V. on behalf of The Japanese Respiratory Society. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Yamaya, Takafumi
Hagiwara, Eri
Baba, Tomohisa
Kitayama, Takaaki
Murohashi, Kota
Higa, Katsuyuki
Sato, Yozo
Otoshi, Ryota
Tabata, Erina
Shintani, Ryota
Okabayashi, Hiroko
Ikeda, Satoshi
Niwa, Takashi
Nakazawa, Atsuhito
Oda, Tsuneyuki
Okuda, Ryo
Sekine, Akimasa
Kitamura, Hideya
Komatsu, Shigeru
Ogura, Takashi
Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title_full Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title_fullStr Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title_full_unstemmed Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title_short Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
title_sort serum krebs von den lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075813/
https://www.ncbi.nlm.nih.gov/pubmed/33965361
http://dx.doi.org/10.1016/j.resinv.2021.04.002
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