Cargando…

Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses. Recruitment and subsequent activation of IRAK4 upon TLR stimulation is mediated by the myeloid differentiation primary response 88 (MYD88) adaptor pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giménez, Neus, Schulz, Ralph, Higashi, Morihiro, Aymerich, Marta, Villamor, Neus, Delgado, Julio, Juan, Manel, López-Guerra, Mònica, Campo, Elias, Rosich, Laia, Seiffert, Martina, Colomer, Dolors
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075947/ https://www.ncbi.nlm.nih.gov/pubmed/31197259 http://dx.doi.org/10.1038/s41375-019-0507-8

Ejemplares similares

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
por: Xargay-Torrent, Sílvia, et al.
Publicado: (2015)

Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
por: López-Guerra, Mónica, et al.
Publicado: (2019)

Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia
por: Gimenez, Neus, et al.
Publicado: (2020)

Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia
por: Giménez, Neus, et al.
Publicado: (2019)

Novel Tools for Diagnosis and Monitoring of AML
por: Guijarro, Francesca, et al.
Publicado: (2023)

CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia
por: Montraveta, Arnau, et al.
Publicado: (2015)

Chronic lymphocytic leukemia and prolymphocytic leukemia. Two coins or two sides of the same coin?
por: Magnano, Laura, et al.
Publicado: (2020)

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma
por: Rosich, Laia, et al.
Publicado: (2014)

Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies
por: Delgado, Julio, et al.
Publicado: (2020)

Clinicobiological Characteristics and Outcomes of Patients with T-Cell Large Granular Lymphocytic Leukemia and Chronic Lymphoproliferative Disorder of Natural Killer Cells from a Single Institution
por: Rivero, Andrea, et al.
Publicado: (2021)

Detection of chromothripsis‐like patterns with a custom array platform for chronic lymphocytic leukemia
por: Salaverria, Itziar, et al.
Publicado: (2015)

Analysis of criteria for treatment initiation in patients with progressive chronic lymphocytic leukemia
por: Mozas, Pablo, et al.
Publicado: (2018)

IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
por: Nadeu, Ferran, et al.
Publicado: (2020)

Clinico‐biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation
por: Bastidas‐Mora, Gabriela, et al.
Publicado: (2021)

Bcl-2(high) mantle cell lymphoma cells are sensitized to acadesine with ABT-199
por: Montraveta, Arnau, et al.
Publicado: (2015)

Serum monoclonal component in chronic lymphocytic leukemia: baseline correlations and prognostic impact
por: Mozas, Pablo, et al.
Publicado: (2020)

SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
por: López-Oreja, Irene, et al.
Publicado: (2023)

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
por: Heine, Simon, et al.
Publicado: (2018)

Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy
por: Silkenstedt, Elisabeth, et al.
Publicado: (2019)

Irak : cinco años después /
por: Rosas, María Cristina
Publicado: (2008)

Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience
por: Mozas, Pablo, et al.
Publicado: (2020)

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
por: Bennett, Joshua, et al.
Publicado: (2022)

Outgrowing IRAK-4
por: Bashyam, Hema
Publicado: (2007)

IRAK signalling in cancer
por: Rhyasen, G W, et al.
Publicado: (2015)

IRAK4 gene polymorphism and odontogenic maxillary sinusitis
por: Pereira, Inês Guerra, et al.
Publicado: (2015)

Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice
por: Bellí, Gemma, et al.
Publicado: (2022)

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma
por: Montraveta, Arnau, et al.
Publicado: (2014)

IRAK-4 Inhibitors for Inflammation
por: Wang, Zhulun, et al.
Publicado: (2009)

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
por: Vollmer, Stefan, et al.
Publicado: (2017)

Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter’s Transformation
por: Ortiz-Maldonado, Valentín, et al.
Publicado: (2022)

IRAK1: oncotarget in MDS and AML
por: Beverly, Levi J., et al.
Publicado: (2014)

Space Competition and Time Delays in Human Range Expansions. Application to the Neolithic Transition
por: Isern, Neus, et al.
Publicado: (2012)

A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses
por: Araujo-Ayala, Ferran, et al.
Publicado: (2023)

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
por: Lin, Su-Chang, et al.
Publicado: (2010)

Deconstructing the relationships between self‐esteem and paranoia in early psychosis: an experience sampling study
por: Monsonet, Manel, et al.
Publicado: (2020)

The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma
por: Valero, Juan Garcia, et al.
Publicado: (2021)

Regulation of innate immune signaling by IRAK proteins
por: Pereira, Milton, et al.
Publicado: (2023)

Cell-Free DNA for Genomic Analysis in Primary Mediastinal Large B-Cell Lymphoma
por: Rivas-Delgado, Alfredo, et al.
Publicado: (2022)

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
por: Ku, Cheng-Lung, et al.
Publicado: (2007)

The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets
por: Kim, Shi Hyoung, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0kg0co9mq1rldnvaskof65jhss