Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth

Despite advances in the systemic treatment of patients with metastatic melanoma using immune checkpoint and tyrosine kinase inhibitors (TKI), the majority of stage IV melanoma patients eventually succumb to the disease. We have previously identified the transcription factor Sox10 as a crucial player...

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Detalles Bibliográficos
Autores principales: Uka, Rexhep, Britschgi, Christian, Krättli, Anja, Matter, Claudia, Mihic, Daniela, Okoniewski, Michal J., Gualandi, Marco, Stupp, Roger, Cinelli, Paolo, Dummer, Reinhard, Levesque, Mitchell P., Shakhova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076051/
https://www.ncbi.nlm.nih.gov/pubmed/32238882
http://dx.doi.org/10.1038/s41388-020-1267-7

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