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Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry
AIMS: To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D). METHODS: We included 79,067 T1D patients aged 6–20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076130/ https://www.ncbi.nlm.nih.gov/pubmed/33483854 http://dx.doi.org/10.1007/s00592-020-01649-8 |
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author | Tittel, Sascha René Dunstheimer, Désirée Hilgard, Dörte Knauth, Burkhild Fröhlich-Reiterer, Elke Galler, Angela Wurm, Michael Holl, Reinhard Walter |
author_facet | Tittel, Sascha René Dunstheimer, Désirée Hilgard, Dörte Knauth, Burkhild Fröhlich-Reiterer, Elke Galler, Angela Wurm, Michael Holl, Reinhard Walter |
author_sort | Tittel, Sascha René |
collection | PubMed |
description | AIMS: To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D). METHODS: We included 79,067 T1D patients aged 6–20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n = 73,699), T1 + CD (n = 3379), T1D + depression (n = 1877), or T1D + CD + depression (n = 112). RESULTS: CD and depression were significantly associated (adjusted OR: 1.25 [1.03–1.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D + CD and T1D + depression compared with T1D only (both p < .001). HbA1c was higher in T1D + depression (9.0% [8.9–9.0]), T1D + CD + depression (8.9% [8.6–9.2]), both compared with T1D only (8.2% [8.2–8.2], all p < .001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D + CD + depression group compared with T1D only (all p < .001). CONCLUSIONS: CD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at (10.1007/s00592-020-01649-8). |
format | Online Article Text |
id | pubmed-8076130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-80761302021-05-05 Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry Tittel, Sascha René Dunstheimer, Désirée Hilgard, Dörte Knauth, Burkhild Fröhlich-Reiterer, Elke Galler, Angela Wurm, Michael Holl, Reinhard Walter Acta Diabetol Original Article AIMS: To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D). METHODS: We included 79,067 T1D patients aged 6–20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n = 73,699), T1 + CD (n = 3379), T1D + depression (n = 1877), or T1D + CD + depression (n = 112). RESULTS: CD and depression were significantly associated (adjusted OR: 1.25 [1.03–1.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D + CD and T1D + depression compared with T1D only (both p < .001). HbA1c was higher in T1D + depression (9.0% [8.9–9.0]), T1D + CD + depression (8.9% [8.6–9.2]), both compared with T1D only (8.2% [8.2–8.2], all p < .001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D + CD + depression group compared with T1D only (all p < .001). CONCLUSIONS: CD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at (10.1007/s00592-020-01649-8). Springer Milan 2021-01-23 2021 /pmc/articles/PMC8076130/ /pubmed/33483854 http://dx.doi.org/10.1007/s00592-020-01649-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Tittel, Sascha René Dunstheimer, Désirée Hilgard, Dörte Knauth, Burkhild Fröhlich-Reiterer, Elke Galler, Angela Wurm, Michael Holl, Reinhard Walter Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title | Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title_full | Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title_fullStr | Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title_full_unstemmed | Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title_short | Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
title_sort | coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076130/ https://www.ncbi.nlm.nih.gov/pubmed/33483854 http://dx.doi.org/10.1007/s00592-020-01649-8 |
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