Cargando…

The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank

BACKGROUND: The association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5–24.9 kg/m(2)) is unclear. METHODS: We examined the association of measures of adiposity with risk of incident cancers of the breast (postmenopausal), endometrium, ovar...

Descripción completa

Detalles Bibliográficos
Autores principales: Arthur, Rhonda S., Dannenberg, Andrew J., Kim, Mimi, Rohan, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076175/
https://www.ncbi.nlm.nih.gov/pubmed/33723399
http://dx.doi.org/10.1038/s41416-020-01210-y
_version_ 1783684641119535104
author Arthur, Rhonda S.
Dannenberg, Andrew J.
Kim, Mimi
Rohan, Thomas E.
author_facet Arthur, Rhonda S.
Dannenberg, Andrew J.
Kim, Mimi
Rohan, Thomas E.
author_sort Arthur, Rhonda S.
collection PubMed
description BACKGROUND: The association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5–24.9 kg/m(2)) is unclear. METHODS: We examined the association of measures of adiposity with risk of incident cancers of the breast (postmenopausal), endometrium, ovary and colon/rectum among 149,928 normal weight individuals (40–70 years) who were enrolled in the UK Biobank cohort between 2006 and 2010. RESULTS: All of the body fat measures were positively associated with invasive postmenopausal breast cancer risk (hazard ratios (HR) for the uppermost quintile (Q5) versus the lowest quintile (Q1) ranged from 1.32 (95% CI: 1.09–1.60) for waist circumference (WC) to 1.56 (1.28–1.90) for BMI). Trunk fat mass index (HR(Q5 vs Q1): 1.72, 95% CI: 1.02–2.89) and WC (HR(Q5 vs Q1): 1.65, 95% CI: 1.01–2.70)) were positively associated with risk of endometrial cancer. Among males, trunk fat:trunk fat free mass ratio, trunk fat:leg fat mass ratio and (HR(Q5 vs Q1): 1.63, 95% CI: 1.02–2.60; 1.92, 1.20–3.07 and 1.68, 1.05–2.66, respectively) were positively associated with colon cancer risk. None of the body fat measures was associated with risk of ovarian cancer or colorectal cancer in women. CONCLUSION: The findings of this study suggest that the current normal weight category based on BMI includes individuals who are at increased risk of some obesity-related cancers.
format Online
Article
Text
id pubmed-8076175
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-80761752022-03-15 The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank Arthur, Rhonda S. Dannenberg, Andrew J. Kim, Mimi Rohan, Thomas E. Br J Cancer Article BACKGROUND: The association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5–24.9 kg/m(2)) is unclear. METHODS: We examined the association of measures of adiposity with risk of incident cancers of the breast (postmenopausal), endometrium, ovary and colon/rectum among 149,928 normal weight individuals (40–70 years) who were enrolled in the UK Biobank cohort between 2006 and 2010. RESULTS: All of the body fat measures were positively associated with invasive postmenopausal breast cancer risk (hazard ratios (HR) for the uppermost quintile (Q5) versus the lowest quintile (Q1) ranged from 1.32 (95% CI: 1.09–1.60) for waist circumference (WC) to 1.56 (1.28–1.90) for BMI). Trunk fat mass index (HR(Q5 vs Q1): 1.72, 95% CI: 1.02–2.89) and WC (HR(Q5 vs Q1): 1.65, 95% CI: 1.01–2.70)) were positively associated with risk of endometrial cancer. Among males, trunk fat:trunk fat free mass ratio, trunk fat:leg fat mass ratio and (HR(Q5 vs Q1): 1.63, 95% CI: 1.02–2.60; 1.92, 1.20–3.07 and 1.68, 1.05–2.66, respectively) were positively associated with colon cancer risk. None of the body fat measures was associated with risk of ovarian cancer or colorectal cancer in women. CONCLUSION: The findings of this study suggest that the current normal weight category based on BMI includes individuals who are at increased risk of some obesity-related cancers. Nature Publishing Group UK 2021-03-15 2021-04-27 /pmc/articles/PMC8076175/ /pubmed/33723399 http://dx.doi.org/10.1038/s41416-020-01210-y Text en © The Author(s), under exclusive licence to Cancer Research UK 2021 https://creativecommons.org/licenses/by/4.0/Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Article
Arthur, Rhonda S.
Dannenberg, Andrew J.
Kim, Mimi
Rohan, Thomas E.
The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title_full The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title_fullStr The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title_full_unstemmed The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title_short The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
title_sort association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076175/
https://www.ncbi.nlm.nih.gov/pubmed/33723399
http://dx.doi.org/10.1038/s41416-020-01210-y
work_keys_str_mv AT arthurrhondas theassociationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT dannenbergandrewj theassociationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT kimmimi theassociationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT rohanthomase theassociationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT arthurrhondas associationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT dannenbergandrewj associationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT kimmimi associationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank
AT rohanthomase associationofbodyfatcompositionwithriskofbreastendometrialovarianandcolorectalcancersamongnormalweightparticipantsintheukbiobank