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Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections
Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and incident infections. In the current study, we assess parasite kinetics and infectivity to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) incident infections following parasite clearance (...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076179/ https://www.ncbi.nlm.nih.gov/pubmed/33903595 http://dx.doi.org/10.1038/s41467-021-22573-7 |
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author | Barry, Aissata Bradley, John Stone, Will Guelbeogo, Moussa W. Lanke, Kjerstin Ouedraogo, Alphonse Soulama, Issiaka Nébié, Issa Serme, Samuel S. Grignard, Lynn Patterson, Catriona Wu, Lindsey Briggs, Jessica J. Janson, Owen Awandu, Shehu S. Ouedraogo, Mireille Tarama, Casimire W. Kargougou, Désiré Zongo, Soumanaba Sirima, Sodiomon B. Marti, Matthias Drakeley, Chris Tiono, Alfred B. Bousema, Teun |
author_facet | Barry, Aissata Bradley, John Stone, Will Guelbeogo, Moussa W. Lanke, Kjerstin Ouedraogo, Alphonse Soulama, Issiaka Nébié, Issa Serme, Samuel S. Grignard, Lynn Patterson, Catriona Wu, Lindsey Briggs, Jessica J. Janson, Owen Awandu, Shehu S. Ouedraogo, Mireille Tarama, Casimire W. Kargougou, Désiré Zongo, Soumanaba Sirima, Sodiomon B. Marti, Matthias Drakeley, Chris Tiono, Alfred B. Bousema, Teun |
author_sort | Barry, Aissata |
collection | PubMed |
description | Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and incident infections. In the current study, we assess parasite kinetics and infectivity to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) incident infections following parasite clearance (n = 48) and (b) chronic asymptomatic infections (n = 60). In the incident infection cohort, 92% (44/48) of children develop symptoms within 35 days, compared to 23% (14/60) in the chronic cohort. All individuals with chronic infection carried gametocytes or developed them during follow-up, whereas only 35% (17/48) in the incident cohort produce gametocytes before becoming symptomatic and receiving treatment. Parasite multiplication rate (PMR) and the relative abundance of ap2-g and gexp-5 transcripts are positively associated with gametocyte production. Antibody responses are higher and PMR lower in chronic infections. The presence of symptoms and sexual stage immune responses are associated with reductions in gametocyte infectivity to mosquitoes. We observe that most incident infections require treatment before the density of mature gametocytes is sufficient to infect mosquitoes. In contrast, chronic, asymptomatic infections represent a significant source of mosquito infections. Our observations support the notion that malaria transmission reduction may be expedited by enhanced case management, involving both symptom-screening and infection detection. |
format | Online Article Text |
id | pubmed-8076179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80761792021-05-11 Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections Barry, Aissata Bradley, John Stone, Will Guelbeogo, Moussa W. Lanke, Kjerstin Ouedraogo, Alphonse Soulama, Issiaka Nébié, Issa Serme, Samuel S. Grignard, Lynn Patterson, Catriona Wu, Lindsey Briggs, Jessica J. Janson, Owen Awandu, Shehu S. Ouedraogo, Mireille Tarama, Casimire W. Kargougou, Désiré Zongo, Soumanaba Sirima, Sodiomon B. Marti, Matthias Drakeley, Chris Tiono, Alfred B. Bousema, Teun Nat Commun Article Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and incident infections. In the current study, we assess parasite kinetics and infectivity to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) incident infections following parasite clearance (n = 48) and (b) chronic asymptomatic infections (n = 60). In the incident infection cohort, 92% (44/48) of children develop symptoms within 35 days, compared to 23% (14/60) in the chronic cohort. All individuals with chronic infection carried gametocytes or developed them during follow-up, whereas only 35% (17/48) in the incident cohort produce gametocytes before becoming symptomatic and receiving treatment. Parasite multiplication rate (PMR) and the relative abundance of ap2-g and gexp-5 transcripts are positively associated with gametocyte production. Antibody responses are higher and PMR lower in chronic infections. The presence of symptoms and sexual stage immune responses are associated with reductions in gametocyte infectivity to mosquitoes. We observe that most incident infections require treatment before the density of mature gametocytes is sufficient to infect mosquitoes. In contrast, chronic, asymptomatic infections represent a significant source of mosquito infections. Our observations support the notion that malaria transmission reduction may be expedited by enhanced case management, involving both symptom-screening and infection detection. Nature Publishing Group UK 2021-04-26 /pmc/articles/PMC8076179/ /pubmed/33903595 http://dx.doi.org/10.1038/s41467-021-22573-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Barry, Aissata Bradley, John Stone, Will Guelbeogo, Moussa W. Lanke, Kjerstin Ouedraogo, Alphonse Soulama, Issiaka Nébié, Issa Serme, Samuel S. Grignard, Lynn Patterson, Catriona Wu, Lindsey Briggs, Jessica J. Janson, Owen Awandu, Shehu S. Ouedraogo, Mireille Tarama, Casimire W. Kargougou, Désiré Zongo, Soumanaba Sirima, Sodiomon B. Marti, Matthias Drakeley, Chris Tiono, Alfred B. Bousema, Teun Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title_full | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title_fullStr | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title_full_unstemmed | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title_short | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections |
title_sort | higher gametocyte production and mosquito infectivity in chronic compared to incident plasmodium falciparum infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076179/ https://www.ncbi.nlm.nih.gov/pubmed/33903595 http://dx.doi.org/10.1038/s41467-021-22573-7 |
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