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CBD, a precursor of THC in e-cigarettes

The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temp...

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Autores principales: Czégény, Zsuzsanna, Nagy, Gréta, Babinszki, Bence, Bajtel, Ákos, Sebestyén, Zoltán, Kiss, Tivadar, Csupor-Löffler, Boglárka, Tóth, Barbara, Csupor, Dezső
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076212/
https://www.ncbi.nlm.nih.gov/pubmed/33903673
http://dx.doi.org/10.1038/s41598-021-88389-z
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author Czégény, Zsuzsanna
Nagy, Gréta
Babinszki, Bence
Bajtel, Ákos
Sebestyén, Zoltán
Kiss, Tivadar
Csupor-Löffler, Boglárka
Tóth, Barbara
Csupor, Dezső
author_facet Czégény, Zsuzsanna
Nagy, Gréta
Babinszki, Bence
Bajtel, Ákos
Sebestyén, Zoltán
Kiss, Tivadar
Csupor-Löffler, Boglárka
Tóth, Barbara
Csupor, Dezső
author_sort Czégény, Zsuzsanna
collection PubMed
description The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250–400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC–MS. Depending on the temperature and atmosphere, 25–52% of CBD was transformed into other chemical substances: Δ(9)-THC, Δ(8)-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes.
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spelling pubmed-80762122021-04-27 CBD, a precursor of THC in e-cigarettes Czégény, Zsuzsanna Nagy, Gréta Babinszki, Bence Bajtel, Ákos Sebestyén, Zoltán Kiss, Tivadar Csupor-Löffler, Boglárka Tóth, Barbara Csupor, Dezső Sci Rep Article The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250–400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC–MS. Depending on the temperature and atmosphere, 25–52% of CBD was transformed into other chemical substances: Δ(9)-THC, Δ(8)-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes. Nature Publishing Group UK 2021-04-26 /pmc/articles/PMC8076212/ /pubmed/33903673 http://dx.doi.org/10.1038/s41598-021-88389-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Czégény, Zsuzsanna
Nagy, Gréta
Babinszki, Bence
Bajtel, Ákos
Sebestyén, Zoltán
Kiss, Tivadar
Csupor-Löffler, Boglárka
Tóth, Barbara
Csupor, Dezső
CBD, a precursor of THC in e-cigarettes
title CBD, a precursor of THC in e-cigarettes
title_full CBD, a precursor of THC in e-cigarettes
title_fullStr CBD, a precursor of THC in e-cigarettes
title_full_unstemmed CBD, a precursor of THC in e-cigarettes
title_short CBD, a precursor of THC in e-cigarettes
title_sort cbd, a precursor of thc in e-cigarettes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076212/
https://www.ncbi.nlm.nih.gov/pubmed/33903673
http://dx.doi.org/10.1038/s41598-021-88389-z
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