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Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies

BACKGROUND: Arginine depletion interferes with pyrimidine metabolism and DNA damage-repair pathways, and pairing arginine deiminase pegylated with 20,000-molecular-weight polyethylene glycol (ADI-PEG20) with platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs. METHODS: This si...

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Detalles Bibliográficos
Autores principales:	Yao, Shuyang, Janku, Filip, Subbiah, Vivek, Stewart, John, Patel, Sapna Pradyuman, Kaseb, Ahmed, Westin, Shannon Neville, Naing, Aung, Tsimberidou, Apostolia Maria, Hong, David, Piha-Paul, Sarina Anne, Shi, Nai, Johnston, Amanda, Bomalaski, John, Fu, Siqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076217/ https://www.ncbi.nlm.nih.gov/pubmed/33674736 http://dx.doi.org/10.1038/s41416-020-01230-8

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