Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines

The intracellular penetration of darunavir, a second-generation HIV protease inhibitor, is limited by the activity of the efflux P-glycoprotein (ABCB1). ABCB1 expression and/or activity levels can vary between individuals due to genetic polymorphisms including the c.1199G>A, c.1236C>T, c.2677G...

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Detalles Bibliográficos
Autores principales: Stillemans, Gabriel, Djokoto, Happy Phanio, Delongie, Kévin-Alexandre, El-Hamdaoui, Halima, Panin, Nadtha, Haufroid, Vincent, Elens, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076219/
https://www.ncbi.nlm.nih.gov/pubmed/33903659
http://dx.doi.org/10.1038/s41598-021-88365-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076219/
https://www.ncbi.nlm.nih.gov/pubmed/33903659
http://dx.doi.org/10.1038/s41598-021-88365-7

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