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Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay

Phosphorylation of the histone protein H2AX to form γ-H2AX foci directly represents DNA double-strand break formation. Traditional γ-H2AX detection involves counting individual foci within individual nuclei. The novelty of this work is the application of a time-resolved fluorescence assay using diss...

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Detalles Bibliográficos
Autores principales:	Noubissi, Felicite K., McBride, Amber A., Leppert, Hannah G., Millet, Larry J., Wang, Xiaofei, Davern, Sandra M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076281/ https://www.ncbi.nlm.nih.gov/pubmed/33903655 http://dx.doi.org/10.1038/s41598-021-88296-3

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