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Single cell plasticity and population coding stability in auditory thalamus upon associative learning
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains unknown. Using a miniature microscope imaging approach, we monitor the activity of popul...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076296/ https://www.ncbi.nlm.nih.gov/pubmed/33903596 http://dx.doi.org/10.1038/s41467-021-22421-8 |
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author | Taylor, James Alexander Hasegawa, Masashi Benoit, Chloé Maëlle Freire, Joana Amorim Theodore, Marine Ganea, Dan Alin Innocenti, Sabrina Milena Lu, Tingjia Gründemann, Jan |
author_facet | Taylor, James Alexander Hasegawa, Masashi Benoit, Chloé Maëlle Freire, Joana Amorim Theodore, Marine Ganea, Dan Alin Innocenti, Sabrina Milena Lu, Tingjia Gründemann, Jan |
author_sort | Taylor, James Alexander |
collection | PubMed |
description | Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains unknown. Using a miniature microscope imaging approach, we monitor the activity of populations of auditory thalamus (medial geniculate body) neurons in freely moving mice upon fear conditioning. We find that single cells exhibit mixed selectivity and heterogeneous plasticity patterns to auditory and aversive stimuli upon learning, which is conserved in amygdala-projecting medial geniculate body neurons. Activity in auditory thalamus to amygdala-projecting neurons stabilizes single cell plasticity in the total medial geniculate body population and is necessary for fear memory consolidation. In contrast to individual cells, population level encoding of auditory stimuli remained stable across days. Our data identifies auditory thalamus as a site for complex neuronal plasticity in fear learning upstream of the amygdala that is in an ideal position to drive plasticity in cortical and limbic brain areas. These findings suggest that medial geniculate body’s role goes beyond a sole relay function by balancing experience-dependent, diverse single cell plasticity with consistent ensemble level representations of the sensory environment to support stable auditory perception with minimal affective bias. |
format | Online Article Text |
id | pubmed-8076296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80762962021-05-11 Single cell plasticity and population coding stability in auditory thalamus upon associative learning Taylor, James Alexander Hasegawa, Masashi Benoit, Chloé Maëlle Freire, Joana Amorim Theodore, Marine Ganea, Dan Alin Innocenti, Sabrina Milena Lu, Tingjia Gründemann, Jan Nat Commun Article Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains unknown. Using a miniature microscope imaging approach, we monitor the activity of populations of auditory thalamus (medial geniculate body) neurons in freely moving mice upon fear conditioning. We find that single cells exhibit mixed selectivity and heterogeneous plasticity patterns to auditory and aversive stimuli upon learning, which is conserved in amygdala-projecting medial geniculate body neurons. Activity in auditory thalamus to amygdala-projecting neurons stabilizes single cell plasticity in the total medial geniculate body population and is necessary for fear memory consolidation. In contrast to individual cells, population level encoding of auditory stimuli remained stable across days. Our data identifies auditory thalamus as a site for complex neuronal plasticity in fear learning upstream of the amygdala that is in an ideal position to drive plasticity in cortical and limbic brain areas. These findings suggest that medial geniculate body’s role goes beyond a sole relay function by balancing experience-dependent, diverse single cell plasticity with consistent ensemble level representations of the sensory environment to support stable auditory perception with minimal affective bias. Nature Publishing Group UK 2021-04-26 /pmc/articles/PMC8076296/ /pubmed/33903596 http://dx.doi.org/10.1038/s41467-021-22421-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Taylor, James Alexander Hasegawa, Masashi Benoit, Chloé Maëlle Freire, Joana Amorim Theodore, Marine Ganea, Dan Alin Innocenti, Sabrina Milena Lu, Tingjia Gründemann, Jan Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title | Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title_full | Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title_fullStr | Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title_full_unstemmed | Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title_short | Single cell plasticity and population coding stability in auditory thalamus upon associative learning |
title_sort | single cell plasticity and population coding stability in auditory thalamus upon associative learning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076296/ https://www.ncbi.nlm.nih.gov/pubmed/33903596 http://dx.doi.org/10.1038/s41467-021-22421-8 |
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