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Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling
BACKGROUND: Circulating tumour DNA (ctDNA) is known as a tumour-specific personalised biomarker, but the mutation-selection criteria from heterogeneous tumours remain a challenge. METHODS: We conducted multiregional sequencing of 42 specimens from 14 colorectal tumours of 12 patients, including two...
Autores principales: | Yaegashi, Mizunori, Iwaya, Takeshi, Sasaki, Noriyuki, Fujita, Masashi, Ju, Zhenlin, Siwak, Doris, Hachiya, Tsuyoshi, Sato, Kei, Endo, Fumitaka, Kimura, Toshimoto, Otsuka, Koki, Sugimoto, Ryo, Sugai, Tamotsu, Liotta, Lance, Lu, Yiling, Mills, Gordon B., Nakagawa, Hidewaki, Nishizuka, Satoshi S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076308/ https://www.ncbi.nlm.nih.gov/pubmed/33658639 http://dx.doi.org/10.1038/s41416-021-01266-4 |
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