Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

GDF15 is a distant TGF-β family member that induces anorexia and weight loss. Due to its function, GDF15 has attracted attention as a potential therapeutic for the treatment of obesity and its associated metabolic diseases. However, the pharmacokinetic and physicochemical properties of GDF15 present...

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Detalles Bibliográficos
Autores principales: Fung, Ella, Kang, Liya, Sapashnik, Diana, Benard, Susan, Sievers, Annette, Liu, Yan, Yan, Guoying, Zhou, Jing, Rodriguez, Linette, Ma, Weijun, Stochaj, Wayne R., LaVallie, Edward, Wroblewska, Liliana, Kelleher, Kerry, Tam, Amy, Bezy, Olivier, Breen, Danna, Chabot, Jeffrey R., He, Tao, Lin, Laura, Wu, Zhidan, Mosyak, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076310/
https://www.ncbi.nlm.nih.gov/pubmed/33903632
http://dx.doi.org/10.1038/s41598-021-87959-5

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