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The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in whic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076496/ https://www.ncbi.nlm.nih.gov/pubmed/33927604 http://dx.doi.org/10.3389/fnbeh.2021.667244 |
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author | Titulaer, Joep Björkholm, Carl Feltmann, Kristin Malmlöf, Torun Mishra, Devesh Bengtsson Gonzales, Carolina Schilström, Björn Konradsson-Geuken, Åsa |
author_facet | Titulaer, Joep Björkholm, Carl Feltmann, Kristin Malmlöf, Torun Mishra, Devesh Bengtsson Gonzales, Carolina Schilström, Björn Konradsson-Geuken, Åsa |
author_sort | Titulaer, Joep |
collection | PubMed |
description | Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty. |
format | Online Article Text |
id | pubmed-8076496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80764962021-04-28 The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory Titulaer, Joep Björkholm, Carl Feltmann, Kristin Malmlöf, Torun Mishra, Devesh Bengtsson Gonzales, Carolina Schilström, Björn Konradsson-Geuken, Åsa Front Behav Neurosci Behavioral Neuroscience Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076496/ /pubmed/33927604 http://dx.doi.org/10.3389/fnbeh.2021.667244 Text en Copyright © 2021 Titulaer, Björkholm, Feltmann, Malmlöf, Mishra, Bengtsson Gonzales, Schilström and Konradsson-Geuken. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Titulaer, Joep Björkholm, Carl Feltmann, Kristin Malmlöf, Torun Mishra, Devesh Bengtsson Gonzales, Carolina Schilström, Björn Konradsson-Geuken, Åsa The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title | The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title_full | The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title_fullStr | The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title_full_unstemmed | The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title_short | The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
title_sort | importance of ventral hippocampal dopamine and norepinephrine in recognition memory |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076496/ https://www.ncbi.nlm.nih.gov/pubmed/33927604 http://dx.doi.org/10.3389/fnbeh.2021.667244 |
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