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The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory

Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in whic...

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Autores principales: Titulaer, Joep, Björkholm, Carl, Feltmann, Kristin, Malmlöf, Torun, Mishra, Devesh, Bengtsson Gonzales, Carolina, Schilström, Björn, Konradsson-Geuken, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076496/
https://www.ncbi.nlm.nih.gov/pubmed/33927604
http://dx.doi.org/10.3389/fnbeh.2021.667244
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author Titulaer, Joep
Björkholm, Carl
Feltmann, Kristin
Malmlöf, Torun
Mishra, Devesh
Bengtsson Gonzales, Carolina
Schilström, Björn
Konradsson-Geuken, Åsa
author_facet Titulaer, Joep
Björkholm, Carl
Feltmann, Kristin
Malmlöf, Torun
Mishra, Devesh
Bengtsson Gonzales, Carolina
Schilström, Björn
Konradsson-Geuken, Åsa
author_sort Titulaer, Joep
collection PubMed
description Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty.
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spelling pubmed-80764962021-04-28 The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory Titulaer, Joep Björkholm, Carl Feltmann, Kristin Malmlöf, Torun Mishra, Devesh Bengtsson Gonzales, Carolina Schilström, Björn Konradsson-Geuken, Åsa Front Behav Neurosci Behavioral Neuroscience Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076496/ /pubmed/33927604 http://dx.doi.org/10.3389/fnbeh.2021.667244 Text en Copyright © 2021 Titulaer, Björkholm, Feltmann, Malmlöf, Mishra, Bengtsson Gonzales, Schilström and Konradsson-Geuken. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Titulaer, Joep
Björkholm, Carl
Feltmann, Kristin
Malmlöf, Torun
Mishra, Devesh
Bengtsson Gonzales, Carolina
Schilström, Björn
Konradsson-Geuken, Åsa
The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title_full The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title_fullStr The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title_full_unstemmed The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title_short The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
title_sort importance of ventral hippocampal dopamine and norepinephrine in recognition memory
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076496/
https://www.ncbi.nlm.nih.gov/pubmed/33927604
http://dx.doi.org/10.3389/fnbeh.2021.667244
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