Cargando…

Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction

Objective: To investigate the clinical characteristics of patients with dizziness/vertigo accompanied by loss of the posterior canal(s) (LPC). Methods: Clinical data of 23 patients with LPC were collected. We determined video-head-impulse test (vHIT) gains of all six semicircular canals and correlat...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zheyuan, Liu, Bo, Si, Hongli, Li, Kangzhi, Shen, Bo, Li, Xiang, Ling, Xia, Yang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076509/
https://www.ncbi.nlm.nih.gov/pubmed/33928099
http://dx.doi.org/10.3389/fmed.2021.589969
_version_ 1783684693160361984
author Li, Zheyuan
Liu, Bo
Si, Hongli
Li, Kangzhi
Shen, Bo
Li, Xiang
Ling, Xia
Yang, Xu
author_facet Li, Zheyuan
Liu, Bo
Si, Hongli
Li, Kangzhi
Shen, Bo
Li, Xiang
Ling, Xia
Yang, Xu
author_sort Li, Zheyuan
collection PubMed
description Objective: To investigate the clinical characteristics of patients with dizziness/vertigo accompanied by loss of the posterior canal(s) (LPC). Methods: Clinical data of 23 patients with LPC were collected. We determined video-head-impulse test (vHIT) gains of all six semicircular canals and correlated vHIT findings with other vestibulo-cochlear tests, including caloric test, ocular and cervical vestibular-evoked myogenic potentials (oVEMP, cVEMP), pure tone audiometry (PTA), and analyzed the differences in clinical manifestations of patients with LPC with different etiologies. Results: LPC was identified in 23 patients. At the time of disease onset, most patients presented with dizziness (47.8%) and vertigo (30.4%) only, and some patients (21.7%) complained of unsteadiness. Among these 23 patients with LPC, there were 14 (60.9%) patients of isolated LPC (ILPC), 21 (91.3%) patients of unilateral LPC (ULPC), and 2 (8.7%) patients of bilateral LPC (BLPC). (1) Among 14 patients with ILPC, 13 (92.9%) patients had unilateral ILPC, the rate of ipsilesional impairment on caloric test, or oVEMP/cVEMP test or PTA ipsilesionally was 53.8% (7/13) in patients with unilateral ILPC. The causes of unilateral ILPC were vertigo/dizziness of unclear origin (38.5%), labyrinthine infarction (15.4%), vestibular migraine (15.4%), and other diseases (30.8%); (2) among 21 patients with ULPC, 7 patients (33.3%) were accompanied with horizontal semicircular canal hypofunction ipsilesionally, the abnormal rate of caloric test, or oVEMP/cVEMP tests or PTA ipsilesionally was 57.1%. The causes of ULPC were vertigo/dizziness of unclear origin (33.3%), autoimmune inner ear disease (14.3%), labyrinthine infarction (14.3%), vestibular neuritis (9.5%), vestibular migraine (9.5%), and other diseases (19.0%); (3) among two patients with BLPC, one patient presented with unsteadiness, the causes of BLPC were vestibular paroxysmia and autoimmune inner ear disease. Conclusion: vHIT is a fast and effective method for assessing LPC, which can be used to detect isolated PC dysfunction. The causes of ILPC were peripheral origin or central origin. Patients with ILPC and ULPC mostly presented with dizziness/vertigo, and ULPC was often accompanied by ipsilateral vestibulo-cochlear impairment.
format Online
Article
Text
id pubmed-8076509
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80765092021-04-28 Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction Li, Zheyuan Liu, Bo Si, Hongli Li, Kangzhi Shen, Bo Li, Xiang Ling, Xia Yang, Xu Front Med (Lausanne) Medicine Objective: To investigate the clinical characteristics of patients with dizziness/vertigo accompanied by loss of the posterior canal(s) (LPC). Methods: Clinical data of 23 patients with LPC were collected. We determined video-head-impulse test (vHIT) gains of all six semicircular canals and correlated vHIT findings with other vestibulo-cochlear tests, including caloric test, ocular and cervical vestibular-evoked myogenic potentials (oVEMP, cVEMP), pure tone audiometry (PTA), and analyzed the differences in clinical manifestations of patients with LPC with different etiologies. Results: LPC was identified in 23 patients. At the time of disease onset, most patients presented with dizziness (47.8%) and vertigo (30.4%) only, and some patients (21.7%) complained of unsteadiness. Among these 23 patients with LPC, there were 14 (60.9%) patients of isolated LPC (ILPC), 21 (91.3%) patients of unilateral LPC (ULPC), and 2 (8.7%) patients of bilateral LPC (BLPC). (1) Among 14 patients with ILPC, 13 (92.9%) patients had unilateral ILPC, the rate of ipsilesional impairment on caloric test, or oVEMP/cVEMP test or PTA ipsilesionally was 53.8% (7/13) in patients with unilateral ILPC. The causes of unilateral ILPC were vertigo/dizziness of unclear origin (38.5%), labyrinthine infarction (15.4%), vestibular migraine (15.4%), and other diseases (30.8%); (2) among 21 patients with ULPC, 7 patients (33.3%) were accompanied with horizontal semicircular canal hypofunction ipsilesionally, the abnormal rate of caloric test, or oVEMP/cVEMP tests or PTA ipsilesionally was 57.1%. The causes of ULPC were vertigo/dizziness of unclear origin (33.3%), autoimmune inner ear disease (14.3%), labyrinthine infarction (14.3%), vestibular neuritis (9.5%), vestibular migraine (9.5%), and other diseases (19.0%); (3) among two patients with BLPC, one patient presented with unsteadiness, the causes of BLPC were vestibular paroxysmia and autoimmune inner ear disease. Conclusion: vHIT is a fast and effective method for assessing LPC, which can be used to detect isolated PC dysfunction. The causes of ILPC were peripheral origin or central origin. Patients with ILPC and ULPC mostly presented with dizziness/vertigo, and ULPC was often accompanied by ipsilateral vestibulo-cochlear impairment. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076509/ /pubmed/33928099 http://dx.doi.org/10.3389/fmed.2021.589969 Text en Copyright © 2021 Li, Liu, Si, Li, Shen, Li, Ling and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Li, Zheyuan
Liu, Bo
Si, Hongli
Li, Kangzhi
Shen, Bo
Li, Xiang
Ling, Xia
Yang, Xu
Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title_full Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title_fullStr Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title_full_unstemmed Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title_short Clinical Characteristics of Patients With Dizziness/Vertigo Accompanied by Posterior Semicircular Canal Hypofunction
title_sort clinical characteristics of patients with dizziness/vertigo accompanied by posterior semicircular canal hypofunction
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076509/
https://www.ncbi.nlm.nih.gov/pubmed/33928099
http://dx.doi.org/10.3389/fmed.2021.589969
work_keys_str_mv AT lizheyuan clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT liubo clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT sihongli clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT likangzhi clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT shenbo clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT lixiang clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT lingxia clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction
AT yangxu clinicalcharacteristicsofpatientswithdizzinessvertigoaccompaniedbyposteriorsemicircularcanalhypofunction