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Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This importan...

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Autores principales: Li, Wenyu, Deng, Xiaorong, Chen, Tingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076595/
https://www.ncbi.nlm.nih.gov/pubmed/33928033
http://dx.doi.org/10.3389/fonc.2021.644454
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author Li, Wenyu
Deng, Xiaorong
Chen, Tingtao
author_facet Li, Wenyu
Deng, Xiaorong
Chen, Tingtao
author_sort Li, Wenyu
collection PubMed
description In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This important role is mainly modulated by the composition of microbiota, as a normal microbiota composition is responsible for maintaining the homeostasis of human body, while an altered microbiota profile could contribute to several pathogenic conditions and may further lead to oncogenesis and tumor progression. Moreover, recent insights have especially focused on the important role of gut microbiota in current anticancer therapies, including chemotherapy, radiotherapy, immunotherapy and surgery. Research findings have indicated a bidirectional interplay between gut microbiota and these therapeutic methods, in which the implementation of different therapeutic methods could lead to different alterations in gut microbiota, and the presence of gut microbiota could in turn contribute to different therapeutic responses. As a result, manipulating the gut microbiota to reduce the therapy-induced toxicity may provide an adjuvant therapy to achieve a better therapeutic outcome. Given the complex role of gut microbiota in cancer treatment, this review summarizes the interactions between gut microbiota and anticancer therapies, and demonstrates the current strategies for reshaping gut microbiota community, aiming to provide possibilities for finding an alternative approach to lower the damage and improve the efficacy of cancer therapy.
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spelling pubmed-80765952021-04-28 Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy Li, Wenyu Deng, Xiaorong Chen, Tingtao Front Oncol Oncology In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This important role is mainly modulated by the composition of microbiota, as a normal microbiota composition is responsible for maintaining the homeostasis of human body, while an altered microbiota profile could contribute to several pathogenic conditions and may further lead to oncogenesis and tumor progression. Moreover, recent insights have especially focused on the important role of gut microbiota in current anticancer therapies, including chemotherapy, radiotherapy, immunotherapy and surgery. Research findings have indicated a bidirectional interplay between gut microbiota and these therapeutic methods, in which the implementation of different therapeutic methods could lead to different alterations in gut microbiota, and the presence of gut microbiota could in turn contribute to different therapeutic responses. As a result, manipulating the gut microbiota to reduce the therapy-induced toxicity may provide an adjuvant therapy to achieve a better therapeutic outcome. Given the complex role of gut microbiota in cancer treatment, this review summarizes the interactions between gut microbiota and anticancer therapies, and demonstrates the current strategies for reshaping gut microbiota community, aiming to provide possibilities for finding an alternative approach to lower the damage and improve the efficacy of cancer therapy. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076595/ /pubmed/33928033 http://dx.doi.org/10.3389/fonc.2021.644454 Text en Copyright © 2021 Li, Deng and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Wenyu
Deng, Xiaorong
Chen, Tingtao
Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title_full Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title_fullStr Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title_full_unstemmed Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title_short Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
title_sort exploring the modulatory effects of gut microbiota in anti-cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076595/
https://www.ncbi.nlm.nih.gov/pubmed/33928033
http://dx.doi.org/10.3389/fonc.2021.644454
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