H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation

Lysine demethylase 6B (KDM6B) is a histone H3 lysine 27 (H3K27) demethylase that serves as a key mediator of gene transcription. Although KDM6B has been reported to modulate neuroinflammation after ischemic stroke, its role in ischemic brain injury is yet to be well elucidated. Therefore, this study...

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Detalles Bibliográficos
Autores principales: Chang, Lisha, An, Zhaowang, Zhang, Jiang, Zhou, Fuling, Wang, Dali, Liu, Jian, Zhang, Yunhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076647/
https://www.ncbi.nlm.nih.gov/pubmed/33981480
http://dx.doi.org/10.1016/j.omtn.2021.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076647/
https://www.ncbi.nlm.nih.gov/pubmed/33981480
http://dx.doi.org/10.1016/j.omtn.2021.01.021

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