Carbohydrate based meningococcal vaccines: past and present overview

Neisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12 N. meningitidis serogroups are differentiated. Six of them,...

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Autores principales: Berti, Francesco, Romano, Maria Rosaria, Micoli, Francesca, Adamo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076658/
https://www.ncbi.nlm.nih.gov/pubmed/33905086
http://dx.doi.org/10.1007/s10719-021-09990-y
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author Berti, Francesco
Romano, Maria Rosaria
Micoli, Francesca
Adamo, Roberto
author_facet Berti, Francesco
Romano, Maria Rosaria
Micoli, Francesca
Adamo, Roberto
author_sort Berti, Francesco
collection PubMed
description Neisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12 N. meningitidis serogroups are differentiated. Six of them, A, B, C, W, X, and Y, cause the vast majority of infections in humans. Mono- and multi-valent carbohydrate-based vaccines against meningococcal infections have been licensed or are currently in clinical development. In this mini-review, an overview of the past and present approaches for producing meningococcal glycoconjugate vaccines is provided.
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spelling pubmed-80766582021-04-27 Carbohydrate based meningococcal vaccines: past and present overview Berti, Francesco Romano, Maria Rosaria Micoli, Francesca Adamo, Roberto Glycoconj J Mini Review Neisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12 N. meningitidis serogroups are differentiated. Six of them, A, B, C, W, X, and Y, cause the vast majority of infections in humans. Mono- and multi-valent carbohydrate-based vaccines against meningococcal infections have been licensed or are currently in clinical development. In this mini-review, an overview of the past and present approaches for producing meningococcal glycoconjugate vaccines is provided. Springer US 2021-04-27 2021 /pmc/articles/PMC8076658/ /pubmed/33905086 http://dx.doi.org/10.1007/s10719-021-09990-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mini Review
Berti, Francesco
Romano, Maria Rosaria
Micoli, Francesca
Adamo, Roberto
Carbohydrate based meningococcal vaccines: past and present overview
title Carbohydrate based meningococcal vaccines: past and present overview
title_full Carbohydrate based meningococcal vaccines: past and present overview
title_fullStr Carbohydrate based meningococcal vaccines: past and present overview
title_full_unstemmed Carbohydrate based meningococcal vaccines: past and present overview
title_short Carbohydrate based meningococcal vaccines: past and present overview
title_sort carbohydrate based meningococcal vaccines: past and present overview
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076658/
https://www.ncbi.nlm.nih.gov/pubmed/33905086
http://dx.doi.org/10.1007/s10719-021-09990-y
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