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Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome

Zika virus was recognized as a teratogen in 2015, when prenatal Zika infection was associated with neonatal microcephaly. The transmission, virulence, tropism, and consequences of Zika virus infection during pregnancy are currently studied. Decreased neural progenitor cells, arrest in neuronal migra...

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Autores principales: Contreras-Capetillo, Silvina Noemí, Palma-Baquedano, José Rafael, Valadéz-González, Nina, Manrique-Saide, Pablo, Barrera-Pérez, Hirian Alonso Moshe, Pinto-Escalante, Doris, Pavía-Ruz, Norma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076683/
https://www.ncbi.nlm.nih.gov/pubmed/33928096
http://dx.doi.org/10.3389/fmed.2021.499016
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author Contreras-Capetillo, Silvina Noemí
Palma-Baquedano, José Rafael
Valadéz-González, Nina
Manrique-Saide, Pablo
Barrera-Pérez, Hirian Alonso Moshe
Pinto-Escalante, Doris
Pavía-Ruz, Norma
author_facet Contreras-Capetillo, Silvina Noemí
Palma-Baquedano, José Rafael
Valadéz-González, Nina
Manrique-Saide, Pablo
Barrera-Pérez, Hirian Alonso Moshe
Pinto-Escalante, Doris
Pavía-Ruz, Norma
author_sort Contreras-Capetillo, Silvina Noemí
collection PubMed
description Zika virus was recognized as a teratogen in 2015, when prenatal Zika infection was associated with neonatal microcephaly. The transmission, virulence, tropism, and consequences of Zika virus infection during pregnancy are currently studied. Decreased neural progenitor cells, arrest in neuronal migration and/or disruption of the maturation process of the fetus central nervous system have been associated. Congenital Zika Syndrome produces a fetal brain disruption sequence resulting in structural brain abnormalities, microcephaly, intracranial calcifications, fetal akinesia and arthrogryposis. Vascular abnormalities like unique umbilical artery and decreased cerebral vascular flow have been described in some patients. This article reports a Zika positive patient with sequence of fetal brain disruption, arthrogryposis and absence of distal third of the right forearm. This report expands the clinical observations of congenital Zika syndrome that may be related to disruptive vascular events.
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spelling pubmed-80766832021-04-28 Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome Contreras-Capetillo, Silvina Noemí Palma-Baquedano, José Rafael Valadéz-González, Nina Manrique-Saide, Pablo Barrera-Pérez, Hirian Alonso Moshe Pinto-Escalante, Doris Pavía-Ruz, Norma Front Med (Lausanne) Medicine Zika virus was recognized as a teratogen in 2015, when prenatal Zika infection was associated with neonatal microcephaly. The transmission, virulence, tropism, and consequences of Zika virus infection during pregnancy are currently studied. Decreased neural progenitor cells, arrest in neuronal migration and/or disruption of the maturation process of the fetus central nervous system have been associated. Congenital Zika Syndrome produces a fetal brain disruption sequence resulting in structural brain abnormalities, microcephaly, intracranial calcifications, fetal akinesia and arthrogryposis. Vascular abnormalities like unique umbilical artery and decreased cerebral vascular flow have been described in some patients. This article reports a Zika positive patient with sequence of fetal brain disruption, arthrogryposis and absence of distal third of the right forearm. This report expands the clinical observations of congenital Zika syndrome that may be related to disruptive vascular events. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076683/ /pubmed/33928096 http://dx.doi.org/10.3389/fmed.2021.499016 Text en Copyright © 2021 Contreras-Capetillo, Palma-Baquedano, Valadéz-González, Manrique-Saide, Barrera-Pérez, Pinto-Escalante and Pavía-Ruz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Contreras-Capetillo, Silvina Noemí
Palma-Baquedano, José Rafael
Valadéz-González, Nina
Manrique-Saide, Pablo
Barrera-Pérez, Hirian Alonso Moshe
Pinto-Escalante, Doris
Pavía-Ruz, Norma
Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title_full Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title_fullStr Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title_full_unstemmed Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title_short Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome
title_sort case report: congenital arthrogryposis and unilateral absences of distal arm in congenital zika syndrome
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076683/
https://www.ncbi.nlm.nih.gov/pubmed/33928096
http://dx.doi.org/10.3389/fmed.2021.499016
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