The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole

In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compoun...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Zhong-jie, Zhou, Ying-jie, Wang, Jia-hao, Mao, Long-fei, Li, Wei, Xu, Gui-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076741/
https://www.ncbi.nlm.nih.gov/pubmed/33928073
http://dx.doi.org/10.3389/fbioe.2021.662432
Descripción
Sumario:In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compound 5e showed good activity against H1975 lung cancer cells, with the half maximal inhibitory concentration (IC(50)) reaching 16.56 μM.

Ejemplares similares