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Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut

BACKGROUND: Healthcare workers (HCWs) are at the front line of the ongoing coronavirus 2019 (COVID-19) pandemic. Comprehensive evaluation of the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among HCWs in a large healthcare system could help to identify the impact of...

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Autores principales: Papasavas, P., Olugbile, S., Wu, U., Robinson, K., Roberts, A.L., O'Sullivan, D.M., McLaughlin, T., Mather, J.F., Steinberg, A.C., Orlando, R., Kumar, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076763/
https://www.ncbi.nlm.nih.gov/pubmed/33930487
http://dx.doi.org/10.1016/j.jhin.2021.04.021
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author Papasavas, P.
Olugbile, S.
Wu, U.
Robinson, K.
Roberts, A.L.
O'Sullivan, D.M.
McLaughlin, T.
Mather, J.F.
Steinberg, A.C.
Orlando, R.
Kumar, A.
author_facet Papasavas, P.
Olugbile, S.
Wu, U.
Robinson, K.
Roberts, A.L.
O'Sullivan, D.M.
McLaughlin, T.
Mather, J.F.
Steinberg, A.C.
Orlando, R.
Kumar, A.
author_sort Papasavas, P.
collection PubMed
description BACKGROUND: Healthcare workers (HCWs) are at the front line of the ongoing coronavirus 2019 (COVID-19) pandemic. Comprehensive evaluation of the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among HCWs in a large healthcare system could help to identify the impact of epidemiological factors and the presence of symptoms on the immune response to the infection over time. AIM: To determine the seroprevalence of SARS-CoV-2-specific antibodies among HCWs, identify associated epidemiological factors and study antibody kinetics. METHODS: A longitudinal evaluation of the seroprevalence and epidemiology of SARS-CoV-2-specific antibodies was undertaken in approximately 30,000 HCWs in the largest healthcare system in Connecticut, USA. FINDINGS: At baseline, the prevalence of SARS-CoV-2 antibody among 6863 HCWs was 6.3% [95% confidence interval (CI) 5.7–6.9%], and was highest among patient care support (16.7%), medical assistants (9.1%) and nurses (8.2%), and lower for physicians (3.8%) and advanced practice providers (4.5%). Seroprevalence was significantly higher among African Americans [odds ratio (OR) 3.26 compared with Caucasians, 95% CI 1.77–5.99], in participants with at least one symptom of COVID-19 (OR 3.00, 95% CI 1.92–4.68), and in those reporting prior quarantine (OR 3.83, 95% CI 2.57–5.70). No symptoms were reported in 24% of seropositive participants. Among the 47% of participants who returned for a follow-up serological test, the seroreversion rate was 39.5% and the seroconversion rate was 2.2%. The incidence of re-infection in the seropositive group was zero. CONCLUSION: Although there is a decline in the immunoglobulin G antibody signal over time, 60.5% of seropositive HCWs had maintained their seroconversion status after a median of 5.5 months.
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spelling pubmed-80767632021-04-27 Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut Papasavas, P. Olugbile, S. Wu, U. Robinson, K. Roberts, A.L. O'Sullivan, D.M. McLaughlin, T. Mather, J.F. Steinberg, A.C. Orlando, R. Kumar, A. J Hosp Infect Article BACKGROUND: Healthcare workers (HCWs) are at the front line of the ongoing coronavirus 2019 (COVID-19) pandemic. Comprehensive evaluation of the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among HCWs in a large healthcare system could help to identify the impact of epidemiological factors and the presence of symptoms on the immune response to the infection over time. AIM: To determine the seroprevalence of SARS-CoV-2-specific antibodies among HCWs, identify associated epidemiological factors and study antibody kinetics. METHODS: A longitudinal evaluation of the seroprevalence and epidemiology of SARS-CoV-2-specific antibodies was undertaken in approximately 30,000 HCWs in the largest healthcare system in Connecticut, USA. FINDINGS: At baseline, the prevalence of SARS-CoV-2 antibody among 6863 HCWs was 6.3% [95% confidence interval (CI) 5.7–6.9%], and was highest among patient care support (16.7%), medical assistants (9.1%) and nurses (8.2%), and lower for physicians (3.8%) and advanced practice providers (4.5%). Seroprevalence was significantly higher among African Americans [odds ratio (OR) 3.26 compared with Caucasians, 95% CI 1.77–5.99], in participants with at least one symptom of COVID-19 (OR 3.00, 95% CI 1.92–4.68), and in those reporting prior quarantine (OR 3.83, 95% CI 2.57–5.70). No symptoms were reported in 24% of seropositive participants. Among the 47% of participants who returned for a follow-up serological test, the seroreversion rate was 39.5% and the seroconversion rate was 2.2%. The incidence of re-infection in the seropositive group was zero. CONCLUSION: Although there is a decline in the immunoglobulin G antibody signal over time, 60.5% of seropositive HCWs had maintained their seroconversion status after a median of 5.5 months. The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2021-08 2021-04-27 /pmc/articles/PMC8076763/ /pubmed/33930487 http://dx.doi.org/10.1016/j.jhin.2021.04.021 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Papasavas, P.
Olugbile, S.
Wu, U.
Robinson, K.
Roberts, A.L.
O'Sullivan, D.M.
McLaughlin, T.
Mather, J.F.
Steinberg, A.C.
Orlando, R.
Kumar, A.
Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title_full Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title_fullStr Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title_full_unstemmed Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title_short Seroprevalence of SARS-CoV-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in Connecticut
title_sort seroprevalence of sars-cov-2 antibodies, associated epidemiological factors and antibody kinetics among healthcare workers in connecticut
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076763/
https://www.ncbi.nlm.nih.gov/pubmed/33930487
http://dx.doi.org/10.1016/j.jhin.2021.04.021
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