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NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate

Complex I (CI) is the largest enzyme of the mitochondrial respiratory chain, and its defects are the main cause of mitochondrial disease. To understand the mechanisms regulating the extremely intricate biogenesis of this fundamental bioenergetic machine, we analyze the structural and functional cons...

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Detalles Bibliográficos
Autores principales:	D’Angelo, Luigi, Astro, Elisa, De Luise, Monica, Kurelac, Ivana, Umesh-Ganesh, Nikkitha, Ding, Shujing, Fearnley, Ian M., Gasparre, Giuseppe, Zeviani, Massimo, Porcelli, Anna Maria, Fernandez-Vizarra, Erika, Iommarini, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076766/ https://www.ncbi.nlm.nih.gov/pubmed/33882309 http://dx.doi.org/10.1016/j.celrep.2021.109002

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