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Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). Howeve...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076851/ https://www.ncbi.nlm.nih.gov/pubmed/33927690 http://dx.doi.org/10.3389/fendo.2021.615446 |
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author | Ishaq, Muhammad Tran, Duyen Wu, Yijia Nowak, Krzysztof Deans, Bianca J. Xin, Joycelin Tan Zhu Loh, Hui Lin Ng, Wen Ying Yee, Chin Wen Southam, Benjamin Vicenzi, Silvia Randall, Cameron Yang, Cheng Tan, Ee Pasupuleti, Manideepika Grewal, Avneet Kaur Ahmad, Tauseef Shastri, Madhur Vicario, Carmelo Ronci, Maurizio Zuccarini, Mariachiara Bleasel, Martin Scowen, Paul Raffaeli, William D’Andrea, Gianvicenzo Chellappan, Dinesh Kumar Jacobson, Glenn Bissember, Alex C. Smith, Jason A. Eri, Raj Canales, Juan Iglesias, Miguel Guven, Nuri Caruso, Vanni |
author_facet | Ishaq, Muhammad Tran, Duyen Wu, Yijia Nowak, Krzysztof Deans, Bianca J. Xin, Joycelin Tan Zhu Loh, Hui Lin Ng, Wen Ying Yee, Chin Wen Southam, Benjamin Vicenzi, Silvia Randall, Cameron Yang, Cheng Tan, Ee Pasupuleti, Manideepika Grewal, Avneet Kaur Ahmad, Tauseef Shastri, Madhur Vicario, Carmelo Ronci, Maurizio Zuccarini, Mariachiara Bleasel, Martin Scowen, Paul Raffaeli, William D’Andrea, Gianvicenzo Chellappan, Dinesh Kumar Jacobson, Glenn Bissember, Alex C. Smith, Jason A. Eri, Raj Canales, Juan Iglesias, Miguel Guven, Nuri Caruso, Vanni |
author_sort | Ishaq, Muhammad |
collection | PubMed |
description | Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). However, the mechanisms by which asperuloside exerts its anti-obesity properties were not clarified. Here, we investigated homeostatic and nutrient-sensing mechanisms regulating food intake in mice consuming HFD. We confirmed the anti-obesity properties of asperuloside and, importantly, we identified some mechanisms that could be responsible for its therapeutic effect. Asperuloside reduced body weight and food intake in mice consuming HFD by 10.5 and 12.8% respectively, with no effect on mice eating a standard chow diet. Fasting glucose and plasma insulin were also significantly reduced. Mechanistically, asperuloside significantly reduced hypothalamic mRNA ghrelin, leptin, and pro-opiomelanocortin in mice consuming HFD. The expression of fat lingual receptors (CD36, FFAR1-4), CB1R and sweet lingual receptors (TAS1R2-3) was increased almost 2-fold by the administration of asperuloside. Our findings suggest that asperuloside might exert its therapeutic effects by altering nutrient-sensing receptors in the oral cavity as well as hypothalamic receptors involved in food intake when mice are exposed to obesogenic diets. This signaling pathway is known to influence the subtle hypothalamic equilibrium between energy homeostasis and reward-induced overeating responses. The present pre-clinical study demonstrated that targeting the gustatory system through asperuloside administration could represent a promising and effective new anti-obesity strategy. |
format | Online Article Text |
id | pubmed-8076851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80768512021-04-28 Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice Ishaq, Muhammad Tran, Duyen Wu, Yijia Nowak, Krzysztof Deans, Bianca J. Xin, Joycelin Tan Zhu Loh, Hui Lin Ng, Wen Ying Yee, Chin Wen Southam, Benjamin Vicenzi, Silvia Randall, Cameron Yang, Cheng Tan, Ee Pasupuleti, Manideepika Grewal, Avneet Kaur Ahmad, Tauseef Shastri, Madhur Vicario, Carmelo Ronci, Maurizio Zuccarini, Mariachiara Bleasel, Martin Scowen, Paul Raffaeli, William D’Andrea, Gianvicenzo Chellappan, Dinesh Kumar Jacobson, Glenn Bissember, Alex C. Smith, Jason A. Eri, Raj Canales, Juan Iglesias, Miguel Guven, Nuri Caruso, Vanni Front Endocrinol (Lausanne) Endocrinology Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). However, the mechanisms by which asperuloside exerts its anti-obesity properties were not clarified. Here, we investigated homeostatic and nutrient-sensing mechanisms regulating food intake in mice consuming HFD. We confirmed the anti-obesity properties of asperuloside and, importantly, we identified some mechanisms that could be responsible for its therapeutic effect. Asperuloside reduced body weight and food intake in mice consuming HFD by 10.5 and 12.8% respectively, with no effect on mice eating a standard chow diet. Fasting glucose and plasma insulin were also significantly reduced. Mechanistically, asperuloside significantly reduced hypothalamic mRNA ghrelin, leptin, and pro-opiomelanocortin in mice consuming HFD. The expression of fat lingual receptors (CD36, FFAR1-4), CB1R and sweet lingual receptors (TAS1R2-3) was increased almost 2-fold by the administration of asperuloside. Our findings suggest that asperuloside might exert its therapeutic effects by altering nutrient-sensing receptors in the oral cavity as well as hypothalamic receptors involved in food intake when mice are exposed to obesogenic diets. This signaling pathway is known to influence the subtle hypothalamic equilibrium between energy homeostasis and reward-induced overeating responses. The present pre-clinical study demonstrated that targeting the gustatory system through asperuloside administration could represent a promising and effective new anti-obesity strategy. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076851/ /pubmed/33927690 http://dx.doi.org/10.3389/fendo.2021.615446 Text en Copyright © 2021 Ishaq, Tran, Wu, Nowak, Deans, Xin, Loh, Ng, Yee, Southam, Vicenzi, Randall, Yang, Tan, Pasupuleti, Grewal, Ahmad, Shastri, Vicario, Ronci, Zuccarini, Bleasel, Scowen, Raffaeli, D’Andrea, Chellappan, Jacobson, Bissember, Smith, Eri, Canales, Iglesias, Guven and Caruso https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Ishaq, Muhammad Tran, Duyen Wu, Yijia Nowak, Krzysztof Deans, Bianca J. Xin, Joycelin Tan Zhu Loh, Hui Lin Ng, Wen Ying Yee, Chin Wen Southam, Benjamin Vicenzi, Silvia Randall, Cameron Yang, Cheng Tan, Ee Pasupuleti, Manideepika Grewal, Avneet Kaur Ahmad, Tauseef Shastri, Madhur Vicario, Carmelo Ronci, Maurizio Zuccarini, Mariachiara Bleasel, Martin Scowen, Paul Raffaeli, William D’Andrea, Gianvicenzo Chellappan, Dinesh Kumar Jacobson, Glenn Bissember, Alex C. Smith, Jason A. Eri, Raj Canales, Juan Iglesias, Miguel Guven, Nuri Caruso, Vanni Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title | Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title_full | Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title_fullStr | Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title_full_unstemmed | Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title_short | Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice |
title_sort | asperuloside enhances taste perception and prevents weight gain in high-fat fed mice |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076851/ https://www.ncbi.nlm.nih.gov/pubmed/33927690 http://dx.doi.org/10.3389/fendo.2021.615446 |
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