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Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice

Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). Howeve...

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Autores principales: Ishaq, Muhammad, Tran, Duyen, Wu, Yijia, Nowak, Krzysztof, Deans, Bianca J., Xin, Joycelin Tan Zhu, Loh, Hui Lin, Ng, Wen Ying, Yee, Chin Wen, Southam, Benjamin, Vicenzi, Silvia, Randall, Cameron, Yang, Cheng, Tan, Ee, Pasupuleti, Manideepika, Grewal, Avneet Kaur, Ahmad, Tauseef, Shastri, Madhur, Vicario, Carmelo, Ronci, Maurizio, Zuccarini, Mariachiara, Bleasel, Martin, Scowen, Paul, Raffaeli, William, D’Andrea, Gianvicenzo, Chellappan, Dinesh Kumar, Jacobson, Glenn, Bissember, Alex C., Smith, Jason A., Eri, Raj, Canales, Juan, Iglesias, Miguel, Guven, Nuri, Caruso, Vanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076851/
https://www.ncbi.nlm.nih.gov/pubmed/33927690
http://dx.doi.org/10.3389/fendo.2021.615446
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author Ishaq, Muhammad
Tran, Duyen
Wu, Yijia
Nowak, Krzysztof
Deans, Bianca J.
Xin, Joycelin Tan Zhu
Loh, Hui Lin
Ng, Wen Ying
Yee, Chin Wen
Southam, Benjamin
Vicenzi, Silvia
Randall, Cameron
Yang, Cheng
Tan, Ee
Pasupuleti, Manideepika
Grewal, Avneet Kaur
Ahmad, Tauseef
Shastri, Madhur
Vicario, Carmelo
Ronci, Maurizio
Zuccarini, Mariachiara
Bleasel, Martin
Scowen, Paul
Raffaeli, William
D’Andrea, Gianvicenzo
Chellappan, Dinesh Kumar
Jacobson, Glenn
Bissember, Alex C.
Smith, Jason A.
Eri, Raj
Canales, Juan
Iglesias, Miguel
Guven, Nuri
Caruso, Vanni
author_facet Ishaq, Muhammad
Tran, Duyen
Wu, Yijia
Nowak, Krzysztof
Deans, Bianca J.
Xin, Joycelin Tan Zhu
Loh, Hui Lin
Ng, Wen Ying
Yee, Chin Wen
Southam, Benjamin
Vicenzi, Silvia
Randall, Cameron
Yang, Cheng
Tan, Ee
Pasupuleti, Manideepika
Grewal, Avneet Kaur
Ahmad, Tauseef
Shastri, Madhur
Vicario, Carmelo
Ronci, Maurizio
Zuccarini, Mariachiara
Bleasel, Martin
Scowen, Paul
Raffaeli, William
D’Andrea, Gianvicenzo
Chellappan, Dinesh Kumar
Jacobson, Glenn
Bissember, Alex C.
Smith, Jason A.
Eri, Raj
Canales, Juan
Iglesias, Miguel
Guven, Nuri
Caruso, Vanni
author_sort Ishaq, Muhammad
collection PubMed
description Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). However, the mechanisms by which asperuloside exerts its anti-obesity properties were not clarified. Here, we investigated homeostatic and nutrient-sensing mechanisms regulating food intake in mice consuming HFD. We confirmed the anti-obesity properties of asperuloside and, importantly, we identified some mechanisms that could be responsible for its therapeutic effect. Asperuloside reduced body weight and food intake in mice consuming HFD by 10.5 and 12.8% respectively, with no effect on mice eating a standard chow diet. Fasting glucose and plasma insulin were also significantly reduced. Mechanistically, asperuloside significantly reduced hypothalamic mRNA ghrelin, leptin, and pro-opiomelanocortin in mice consuming HFD. The expression of fat lingual receptors (CD36, FFAR1-4), CB1R and sweet lingual receptors (TAS1R2-3) was increased almost 2-fold by the administration of asperuloside. Our findings suggest that asperuloside might exert its therapeutic effects by altering nutrient-sensing receptors in the oral cavity as well as hypothalamic receptors involved in food intake when mice are exposed to obesogenic diets. This signaling pathway is known to influence the subtle hypothalamic equilibrium between energy homeostasis and reward-induced overeating responses. The present pre-clinical study demonstrated that targeting the gustatory system through asperuloside administration could represent a promising and effective new anti-obesity strategy.
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spelling pubmed-80768512021-04-28 Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice Ishaq, Muhammad Tran, Duyen Wu, Yijia Nowak, Krzysztof Deans, Bianca J. Xin, Joycelin Tan Zhu Loh, Hui Lin Ng, Wen Ying Yee, Chin Wen Southam, Benjamin Vicenzi, Silvia Randall, Cameron Yang, Cheng Tan, Ee Pasupuleti, Manideepika Grewal, Avneet Kaur Ahmad, Tauseef Shastri, Madhur Vicario, Carmelo Ronci, Maurizio Zuccarini, Mariachiara Bleasel, Martin Scowen, Paul Raffaeli, William D’Andrea, Gianvicenzo Chellappan, Dinesh Kumar Jacobson, Glenn Bissember, Alex C. Smith, Jason A. Eri, Raj Canales, Juan Iglesias, Miguel Guven, Nuri Caruso, Vanni Front Endocrinol (Lausanne) Endocrinology Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). However, the mechanisms by which asperuloside exerts its anti-obesity properties were not clarified. Here, we investigated homeostatic and nutrient-sensing mechanisms regulating food intake in mice consuming HFD. We confirmed the anti-obesity properties of asperuloside and, importantly, we identified some mechanisms that could be responsible for its therapeutic effect. Asperuloside reduced body weight and food intake in mice consuming HFD by 10.5 and 12.8% respectively, with no effect on mice eating a standard chow diet. Fasting glucose and plasma insulin were also significantly reduced. Mechanistically, asperuloside significantly reduced hypothalamic mRNA ghrelin, leptin, and pro-opiomelanocortin in mice consuming HFD. The expression of fat lingual receptors (CD36, FFAR1-4), CB1R and sweet lingual receptors (TAS1R2-3) was increased almost 2-fold by the administration of asperuloside. Our findings suggest that asperuloside might exert its therapeutic effects by altering nutrient-sensing receptors in the oral cavity as well as hypothalamic receptors involved in food intake when mice are exposed to obesogenic diets. This signaling pathway is known to influence the subtle hypothalamic equilibrium between energy homeostasis and reward-induced overeating responses. The present pre-clinical study demonstrated that targeting the gustatory system through asperuloside administration could represent a promising and effective new anti-obesity strategy. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076851/ /pubmed/33927690 http://dx.doi.org/10.3389/fendo.2021.615446 Text en Copyright © 2021 Ishaq, Tran, Wu, Nowak, Deans, Xin, Loh, Ng, Yee, Southam, Vicenzi, Randall, Yang, Tan, Pasupuleti, Grewal, Ahmad, Shastri, Vicario, Ronci, Zuccarini, Bleasel, Scowen, Raffaeli, D’Andrea, Chellappan, Jacobson, Bissember, Smith, Eri, Canales, Iglesias, Guven and Caruso https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ishaq, Muhammad
Tran, Duyen
Wu, Yijia
Nowak, Krzysztof
Deans, Bianca J.
Xin, Joycelin Tan Zhu
Loh, Hui Lin
Ng, Wen Ying
Yee, Chin Wen
Southam, Benjamin
Vicenzi, Silvia
Randall, Cameron
Yang, Cheng
Tan, Ee
Pasupuleti, Manideepika
Grewal, Avneet Kaur
Ahmad, Tauseef
Shastri, Madhur
Vicario, Carmelo
Ronci, Maurizio
Zuccarini, Mariachiara
Bleasel, Martin
Scowen, Paul
Raffaeli, William
D’Andrea, Gianvicenzo
Chellappan, Dinesh Kumar
Jacobson, Glenn
Bissember, Alex C.
Smith, Jason A.
Eri, Raj
Canales, Juan
Iglesias, Miguel
Guven, Nuri
Caruso, Vanni
Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title_full Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title_fullStr Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title_full_unstemmed Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title_short Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
title_sort asperuloside enhances taste perception and prevents weight gain in high-fat fed mice
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076851/
https://www.ncbi.nlm.nih.gov/pubmed/33927690
http://dx.doi.org/10.3389/fendo.2021.615446
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