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Methionine Redox Homeostasis in Protein Quality Control
Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress. Under such conditions, methionine residues are conve...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076862/ https://www.ncbi.nlm.nih.gov/pubmed/33928125 http://dx.doi.org/10.3389/fmolb.2021.665492 |
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author | Aussel, Laurent Ezraty, Benjamin |
author_facet | Aussel, Laurent Ezraty, Benjamin |
author_sort | Aussel, Laurent |
collection | PubMed |
description | Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress. Under such conditions, methionine residues are converted into methionine sulfoxide (Met-O) which can alter protein function. In this review, we focus on the role in protein quality control of methionine sulfoxide reductases (Msr) which repair oxidatively protein-bound Met-O. We discuss our current understanding of the importance of Msr systems in rescuing protein function under oxidative stress and their ability to work in coordination with chaperone networks. Moreover, we highlight that bacterial chaperones, like GroEL or SurA, are also targeted by oxidative stress and under the surveillance of Msr. Therefore, integration of methionine redox homeostasis in protein quality control during oxidative stress gives a complete picture of this bacterial adaptive mechanism. |
format | Online Article Text |
id | pubmed-8076862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80768622021-04-28 Methionine Redox Homeostasis in Protein Quality Control Aussel, Laurent Ezraty, Benjamin Front Mol Biosci Molecular Biosciences Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress. Under such conditions, methionine residues are converted into methionine sulfoxide (Met-O) which can alter protein function. In this review, we focus on the role in protein quality control of methionine sulfoxide reductases (Msr) which repair oxidatively protein-bound Met-O. We discuss our current understanding of the importance of Msr systems in rescuing protein function under oxidative stress and their ability to work in coordination with chaperone networks. Moreover, we highlight that bacterial chaperones, like GroEL or SurA, are also targeted by oxidative stress and under the surveillance of Msr. Therefore, integration of methionine redox homeostasis in protein quality control during oxidative stress gives a complete picture of this bacterial adaptive mechanism. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8076862/ /pubmed/33928125 http://dx.doi.org/10.3389/fmolb.2021.665492 Text en Copyright © 2021 Aussel and Ezraty. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Aussel, Laurent Ezraty, Benjamin Methionine Redox Homeostasis in Protein Quality Control |
title | Methionine Redox Homeostasis in Protein Quality Control |
title_full | Methionine Redox Homeostasis in Protein Quality Control |
title_fullStr | Methionine Redox Homeostasis in Protein Quality Control |
title_full_unstemmed | Methionine Redox Homeostasis in Protein Quality Control |
title_short | Methionine Redox Homeostasis in Protein Quality Control |
title_sort | methionine redox homeostasis in protein quality control |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076862/ https://www.ncbi.nlm.nih.gov/pubmed/33928125 http://dx.doi.org/10.3389/fmolb.2021.665492 |
work_keys_str_mv | AT aussellaurent methionineredoxhomeostasisinproteinqualitycontrol AT ezratybenjamin methionineredoxhomeostasisinproteinqualitycontrol |