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Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men

OBJECTIVE: Compelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a p...

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Autores principales: Chen, Hua, Hemmingsson, Tomas, Janszky, Imre, Rostila, Mikael, Forsell, Yvonne, Meng, Linghui, Liang, Yajun, László, Krisztina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076918/
https://www.ncbi.nlm.nih.gov/pubmed/33903141
http://dx.doi.org/10.1136/bmjopen-2020-043657
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author Chen, Hua
Hemmingsson, Tomas
Janszky, Imre
Rostila, Mikael
Forsell, Yvonne
Meng, Linghui
Liang, Yajun
László, Krisztina D.
author_facet Chen, Hua
Hemmingsson, Tomas
Janszky, Imre
Rostila, Mikael
Forsell, Yvonne
Meng, Linghui
Liang, Yajun
László, Krisztina D.
author_sort Chen, Hua
collection PubMed
description OBJECTIVE: Compelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a parent during childhood and blood pressure in early adulthood in men. SETTING: Sweden. PARTICIPANTS: We studied 48 624 men born in 1949–1951 who participated in the compulsory military conscription in 1969/1970 in Sweden. Information on death of a parent during childhood was obtained from population-based registers. Information on covariates was obtained from the questionnaire and the clinical examination completed at conscription and from population-based registers. OUTCOME MEASURES: Blood pressure was measured at conscription according to standard procedures. RESULTS: The multivariable least square means of systolic and diastolic blood pressure did not differ between bereaved (128.25 (127.04–129.46) and 73.86 (72.89–74.84) mm Hg) and non-bereaved study participants (128.02 (126.86–129.18) and 73.99 (73.06–74.93) mm Hg). Results were similar when considering the cause of the parent’s death, the gender of the deceased parent or the child’s age at loss. Loss of a parent in childhood tended to be associated with an increased hypertension risk (OR and 95% CI: 1.10 (1 to 1.20)); the association was present only in case of natural deaths. CONCLUSION: We found no strong support for the hypothesis that stress following the loss of a parent during childhood is associated with blood pressure or hypertension in youth in men.
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spelling pubmed-80769182021-05-11 Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men Chen, Hua Hemmingsson, Tomas Janszky, Imre Rostila, Mikael Forsell, Yvonne Meng, Linghui Liang, Yajun László, Krisztina D. BMJ Open Epidemiology OBJECTIVE: Compelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a parent during childhood and blood pressure in early adulthood in men. SETTING: Sweden. PARTICIPANTS: We studied 48 624 men born in 1949–1951 who participated in the compulsory military conscription in 1969/1970 in Sweden. Information on death of a parent during childhood was obtained from population-based registers. Information on covariates was obtained from the questionnaire and the clinical examination completed at conscription and from population-based registers. OUTCOME MEASURES: Blood pressure was measured at conscription according to standard procedures. RESULTS: The multivariable least square means of systolic and diastolic blood pressure did not differ between bereaved (128.25 (127.04–129.46) and 73.86 (72.89–74.84) mm Hg) and non-bereaved study participants (128.02 (126.86–129.18) and 73.99 (73.06–74.93) mm Hg). Results were similar when considering the cause of the parent’s death, the gender of the deceased parent or the child’s age at loss. Loss of a parent in childhood tended to be associated with an increased hypertension risk (OR and 95% CI: 1.10 (1 to 1.20)); the association was present only in case of natural deaths. CONCLUSION: We found no strong support for the hypothesis that stress following the loss of a parent during childhood is associated with blood pressure or hypertension in youth in men. BMJ Publishing Group 2021-04-26 /pmc/articles/PMC8076918/ /pubmed/33903141 http://dx.doi.org/10.1136/bmjopen-2020-043657 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Chen, Hua
Hemmingsson, Tomas
Janszky, Imre
Rostila, Mikael
Forsell, Yvonne
Meng, Linghui
Liang, Yajun
László, Krisztina D.
Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title_full Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title_fullStr Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title_full_unstemmed Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title_short Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
title_sort death of a parent during childhood and blood pressure in youth: a population-based cohort study of swedish men
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076918/
https://www.ncbi.nlm.nih.gov/pubmed/33903141
http://dx.doi.org/10.1136/bmjopen-2020-043657
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