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Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

OBJECTIVE: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variabl...

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Autores principales: Garces, María Fernanda, Rodriguez - Navarro, Haiver Antonio, Buell - Acosta, Julieth Daniela, Burgos - Cardenas, Alvaro Javier, Franco - Vega, Roberto, Maldonado - Acosta, Luis Miguel, Eslava - Schmalbach, Javier, Parada - Baños, Arturo José, Castro - Pinzon, Andres, Sanchez, Elizabeth, Angel - Muller, Edith, Lacunza, Ezequiel, Castaño, Justo P., Dieguez, Carlos, Nogueiras, Rubén, Ruiz - Parra, Ariel Ivan, Caminos, Jorge Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077029/
https://www.ncbi.nlm.nih.gov/pubmed/33927698
http://dx.doi.org/10.3389/fendo.2021.670357
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author Garces, María Fernanda
Rodriguez - Navarro, Haiver Antonio
Buell - Acosta, Julieth Daniela
Burgos - Cardenas, Alvaro Javier
Franco - Vega, Roberto
Maldonado - Acosta, Luis Miguel
Eslava - Schmalbach, Javier
Parada - Baños, Arturo José
Castro - Pinzon, Andres
Sanchez, Elizabeth
Angel - Muller, Edith
Lacunza, Ezequiel
Castaño, Justo P.
Dieguez, Carlos
Nogueiras, Rubén
Ruiz - Parra, Ariel Ivan
Caminos, Jorge Eduardo
author_facet Garces, María Fernanda
Rodriguez - Navarro, Haiver Antonio
Buell - Acosta, Julieth Daniela
Burgos - Cardenas, Alvaro Javier
Franco - Vega, Roberto
Maldonado - Acosta, Luis Miguel
Eslava - Schmalbach, Javier
Parada - Baños, Arturo José
Castro - Pinzon, Andres
Sanchez, Elizabeth
Angel - Muller, Edith
Lacunza, Ezequiel
Castaño, Justo P.
Dieguez, Carlos
Nogueiras, Rubén
Ruiz - Parra, Ariel Ivan
Caminos, Jorge Eduardo
author_sort Garces, María Fernanda
collection PubMed
description OBJECTIVE: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. METHODS: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. RESULTS: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) CONCLUSIONS: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.
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spelling pubmed-80770292021-04-28 Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women Garces, María Fernanda Rodriguez - Navarro, Haiver Antonio Buell - Acosta, Julieth Daniela Burgos - Cardenas, Alvaro Javier Franco - Vega, Roberto Maldonado - Acosta, Luis Miguel Eslava - Schmalbach, Javier Parada - Baños, Arturo José Castro - Pinzon, Andres Sanchez, Elizabeth Angel - Muller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz - Parra, Ariel Ivan Caminos, Jorge Eduardo Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. METHODS: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. RESULTS: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) CONCLUSIONS: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8077029/ /pubmed/33927698 http://dx.doi.org/10.3389/fendo.2021.670357 Text en Copyright © 2021 Garces, Rodriguez - Navarro, Buell - Acosta, Burgos - Cardenas, Franco - Vega, Maldonado - Acosta, Eslava - Schmalbach, Parada - Baños, Castro - Pinzon, Sanchez, Angel - Muller, Lacunza, Castaño, Dieguez, Nogueiras, Ruiz - Parra and Caminos https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Garces, María Fernanda
Rodriguez - Navarro, Haiver Antonio
Buell - Acosta, Julieth Daniela
Burgos - Cardenas, Alvaro Javier
Franco - Vega, Roberto
Maldonado - Acosta, Luis Miguel
Eslava - Schmalbach, Javier
Parada - Baños, Arturo José
Castro - Pinzon, Andres
Sanchez, Elizabeth
Angel - Muller, Edith
Lacunza, Ezequiel
Castaño, Justo P.
Dieguez, Carlos
Nogueiras, Rubén
Ruiz - Parra, Ariel Ivan
Caminos, Jorge Eduardo
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title_full Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title_fullStr Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title_full_unstemmed Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title_short Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
title_sort maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077029/
https://www.ncbi.nlm.nih.gov/pubmed/33927698
http://dx.doi.org/10.3389/fendo.2021.670357
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