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‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse

Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we aim to review the evidence for the misuse of zolpidem and describe several related cases collected in...

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Autores principales: Orsolini, Laura, Chiappini, Stefania, Grandinetti, Paolo, Bruschi, Angelo, Testa, Roberta, Provenzano, Alessandra, Berardis, Domenico De, Volpe, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/
https://www.ncbi.nlm.nih.gov/pubmed/33888666
http://dx.doi.org/10.9758/cpn.2021.19.2.367
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author Orsolini, Laura
Chiappini, Stefania
Grandinetti, Paolo
Bruschi, Angelo
Testa, Roberta
Provenzano, Alessandra
Berardis, Domenico De
Volpe, Umberto
author_facet Orsolini, Laura
Chiappini, Stefania
Grandinetti, Paolo
Bruschi, Angelo
Testa, Roberta
Provenzano, Alessandra
Berardis, Domenico De
Volpe, Umberto
author_sort Orsolini, Laura
collection PubMed
description Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we aim to review the evidence for the misuse of zolpidem and describe several related cases collected in Italy. A comprehensive overview is here carried by using several databases, and by combining the search strategy of free text terms and exploding a range of MESH headings relating to the topics of Zolpidem and Abuse and/or Misuse as follows: ((Zolpidem[Title/Abstract]) AND (Abuse[Title/Abstract]) OR (Misuse[Title/Abstract])), without time and/or language restrictions. Furthermore, a case series of 8 cases of zolpidem misuse and/or abuse, collected in different Italian psychiatric settings (psychiatric public hospital, psychiatric private rehabilitation clinic, and private practice), have been here described. According to our findings, zolpidem should be prescribed with the same caution as BZDs, especially in patients with a history of drug abuse or in the elderly. Behavioural modifications, including bizarre behaviours, psychomotor agitation, sleep-related complex behaviours have been reported. Monitoring of zolpidem use in selected populations is warranted. Psychiatrists and physicians should be aware of the misuse potential of zolpidem and adopt measures restricting its use.
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spelling pubmed-80770482021-05-31 ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse Orsolini, Laura Chiappini, Stefania Grandinetti, Paolo Bruschi, Angelo Testa, Roberta Provenzano, Alessandra Berardis, Domenico De Volpe, Umberto Clin Psychopharmacol Neurosci Case Report Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we aim to review the evidence for the misuse of zolpidem and describe several related cases collected in Italy. A comprehensive overview is here carried by using several databases, and by combining the search strategy of free text terms and exploding a range of MESH headings relating to the topics of Zolpidem and Abuse and/or Misuse as follows: ((Zolpidem[Title/Abstract]) AND (Abuse[Title/Abstract]) OR (Misuse[Title/Abstract])), without time and/or language restrictions. Furthermore, a case series of 8 cases of zolpidem misuse and/or abuse, collected in different Italian psychiatric settings (psychiatric public hospital, psychiatric private rehabilitation clinic, and private practice), have been here described. According to our findings, zolpidem should be prescribed with the same caution as BZDs, especially in patients with a history of drug abuse or in the elderly. Behavioural modifications, including bizarre behaviours, psychomotor agitation, sleep-related complex behaviours have been reported. Monitoring of zolpidem use in selected populations is warranted. Psychiatrists and physicians should be aware of the misuse potential of zolpidem and adopt measures restricting its use. Korean College of Neuropsychopharmacology 2021-05-31 2021-05-31 /pmc/articles/PMC8077048/ /pubmed/33888666 http://dx.doi.org/10.9758/cpn.2021.19.2.367 Text en Copyright© 2021, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Orsolini, Laura
Chiappini, Stefania
Grandinetti, Paolo
Bruschi, Angelo
Testa, Roberta
Provenzano, Alessandra
Berardis, Domenico De
Volpe, Umberto
‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title_full ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title_fullStr ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title_full_unstemmed ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title_short ‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse
title_sort ‘z-trip’? a comprehensive overview and a case-series of zolpidem misuse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/
https://www.ncbi.nlm.nih.gov/pubmed/33888666
http://dx.doi.org/10.9758/cpn.2021.19.2.367
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