Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia

BACKGROUND: The Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided. METHODS: Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change. RESULTS:...

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Autores principales: Sekula, Raymond F., Deeley, Kathleen, Denwood, Hayley, Vieira, Alexandre R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077135/
https://www.ncbi.nlm.nih.gov/pubmed/33428824
http://dx.doi.org/10.1002/mgg3.1587
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author Sekula, Raymond F.
Deeley, Kathleen
Denwood, Hayley
Vieira, Alexandre R.
author_facet Sekula, Raymond F.
Deeley, Kathleen
Denwood, Hayley
Vieira, Alexandre R.
author_sort Sekula, Raymond F.
collection PubMed
description BACKGROUND: The Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided. METHODS: Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change. RESULTS: No cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A. CONCLUSION: Met136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia.
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spelling pubmed-80771352021-04-29 Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia Sekula, Raymond F. Deeley, Kathleen Denwood, Hayley Vieira, Alexandre R. Mol Genet Genomic Med Letter to the Editor BACKGROUND: The Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided. METHODS: Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change. RESULTS: No cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A. CONCLUSION: Met136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia. John Wiley and Sons Inc. 2021-01-11 /pmc/articles/PMC8077135/ /pubmed/33428824 http://dx.doi.org/10.1002/mgg3.1587 Text en © 2021 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Sekula, Raymond F.
Deeley, Kathleen
Denwood, Hayley
Vieira, Alexandre R.
Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title_full Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title_fullStr Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title_full_unstemmed Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title_short Gain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
title_sort gain‐of‐function mutation met136val in scn8a may not be a common cause of trigeminal neuralgia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077135/
https://www.ncbi.nlm.nih.gov/pubmed/33428824
http://dx.doi.org/10.1002/mgg3.1587
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