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Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Mavacamten (MYK-461) is a small-molecule allosteric inhibitor of sarcomeric myosins being used in preclinical/clinical trials for hypertrophic cardiomyopathy treatment. A better understanding of its impact on force generation in intact or skinned striated muscle preparations, especially for human ca...

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Detalles Bibliográficos
Autores principales:	Scellini, Beatrice, Piroddi, Nicoletta, Dente, Marica, Vitale, Giulia, Pioner, Josè Manuel, Coppini, Raffaele, Ferrantini, Cecilia, Poggesi, Corrado, Tesi, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077167/ https://www.ncbi.nlm.nih.gov/pubmed/33891673 http://dx.doi.org/10.1085/jgp.202012789

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