Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account...

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Detalles Bibliográficos
Autores principales: Bastard, Paul, Orlova, Elizaveta, Sozaeva, Leila, Lévy, Romain, James, Alyssa, Schmitt, Monica M., Ochoa, Sebastian, Kareva, Maria, Rodina, Yulia, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Neehus, Anna-Lena, Shaw, Elana, Migaud, Mélanie, Bizien, Lucy, Ekwall, Olov, Berg, Stefan, Beccuti, Guglielmo, Ghizzoni, Lucia, Thiriez, Gérard, Pavot, Arthur, Goujard, Cécile, Frémond, Marie-Louise, Carter, Edwin, Rothenbuhler, Anya, Linglart, Agnès, Mignot, Brigite, Comte, Aurélie, Cheikh, Nathalie, Hermine, Olivier, Breivik, Lars, Husebye, Eystein S., Humbert, Sébastien, Rohrlich, Pierre, Coaquette, Alain, Vuoto, Fanny, Faure, Karine, Mahlaoui, Nizar, Kotnik, Primož, Battelino, Tadej, Trebušak Podkrajšek, Katarina, Kisand, Kai, Ferré, Elise M.N., DiMaggio, Thomas, Rosen, Lindsey B., Burbelo, Peter D., McIntyre, Martin, Kann, Nelli Y., Shcherbina, Anna, Pavlova, Maria, Kolodkina, Anna, Holland, Steven M., Zhang, Shen-Ying, Crow, Yanick J., Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Anderson, Mark S., Jouanguy, Emmanuelle, Neven, Bénédicte, Puel, Anne, Casanova, Jean-Laurent, Lionakis, Michail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077172/
https://www.ncbi.nlm.nih.gov/pubmed/33890986
http://dx.doi.org/10.1084/jem.20210554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077172/
https://www.ncbi.nlm.nih.gov/pubmed/33890986
http://dx.doi.org/10.1084/jem.20210554

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