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Natural killer cell immune synapse formation and cytotoxicity are controlled by tension of the target interface

Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse. Diseased cells may exhibit altered mechanical properties but how this impacts NK cell responsiveness is unknown. We report that human NK cells were stimulated more effectively to secrete granzymes A and B, F...

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Detalles Bibliográficos
Autores principales:	Friedman, Daniel, Simmonds, Poppy, Hale, Alexander, Bere, Leoma, Hodson, Nigel W., White, Michael R. H., Davis, Daniel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077183/ https://www.ncbi.nlm.nih.gov/pubmed/33712452 http://dx.doi.org/10.1242/jcs.258570

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